For chemists, researchers, and product developers, a thorough understanding of a compound's chemical properties is fundamental to its successful application. 4'-Hydroxypropiophenone, identified by its CAS number 70-70-2, is an organic compound that offers a compelling profile of chemical characteristics, making it a valuable asset across multiple industrial sectors, from pharmaceuticals to cosmetics and fine chemicals. This article explores its key properties and diverse application landscape.

Chemical Profile of 4'-Hydroxypropiophenone

4'-Hydroxypropiophenone is an aromatic ketone with the molecular formula C9H10O2 and a molecular weight of approximately 150.18 g/mol. Its structure features a phenyl ring substituted with a hydroxyl group (-OH) at the para position and a propiophenone group (-C(=O)CH2CH3). This specific arrangement of functional groups contributes to its reactivity and utility in various chemical processes.

Key Chemical and Physical Properties

  • Purity: Typically supplied with a high purity level, often stated as ≥99.0% by High-Performance Liquid Chromatography (HPLC), ensuring minimal impurities for sensitive applications. This high purity is critical for its role as a pharmaceutical intermediate.
  • Appearance: It commonly presents as a white to off-white or tan crystalline powder, indicative of its solid state at room temperature.
  • Melting Point: While sources vary slightly, its melting point is generally reported in the range of 148-152°C, signifying a stable crystalline structure. This solid form simplifies handling and storage for manufacturers.
  • Solubility: Its solubility characteristics are important for formulation and reaction design. It shows limited solubility in water (around 0.34 g/L at 15°C) but is generally soluble in organic solvents like ethanol, methanol, and acetone.
  • Boiling Point: The boiling point is around 299-300°C at atmospheric pressure, indicating its thermal stability under typical processing conditions.
  • Antioxidant Activity: The phenolic hydroxyl group confers antioxidant properties, allowing it to scavenge free radicals, which is beneficial in cosmetic and certain pharmaceutical applications.

Diverse Industrial Applications

The chemical versatility of 4'-Hydroxypropiophenone translates into a broad spectrum of applications:

  • Pharmaceutical Intermediates: It is a key building block for synthesizing analgesic and anti-inflammatory drugs. Researchers and pharmaceutical manufacturers often purchase this compound in bulk for large-scale API production.
  • Cosmetic Ingredients: Valued for its antioxidant and potential UV-absorbing properties, it is used in skincare products to protect against oxidative stress and environmental damage. Cosmetic formulators rely on its consistent quality.
  • Fine Chemical Synthesis: Its functional groups make it an excellent starting material for creating a wide array of fine chemicals, specialty polymers, and custom synthesized molecules.
  • Flavor and Fragrance: Possesses a characteristic aroma that makes it a useful additive in certain flavor and fragrance formulations.

Sourcing and Quality Assurance

For businesses requiring 4'-Hydroxypropiophenone, whether for R&D or large-scale production, sourcing from reputable manufacturers is essential. Key considerations include verifying purity specifications (≥99.0% HPLC), availability of Certificates of Analysis (COA), and secure supply chains. Manufacturers in China are significant suppliers, offering competitive pricing and bulk purchase options. Procurement specialists should always request quotes and discuss delivery terms (FOB, CIF) to ensure cost-effectiveness and timely delivery of this crucial chemical building block.

In conclusion, 4'-Hydroxypropiophenone's well-defined chemical properties, coupled with its diverse applications, solidify its position as a valuable compound for the chemical, pharmaceutical, and cosmetic industries. Understanding these attributes empowers chemists and procurement professionals to leverage its full potential.