5-Bromoindole (CAS 10075-50-0) is a compound of significant interest in organic chemistry, primarily recognized for its role as a versatile intermediate in the synthesis of pharmaceuticals and fine chemicals. Understanding its chemical properties is key to appreciating its broad applicability. As a dedicated manufacturer and supplier of high-quality chemical intermediates from China, we provide this essential compound to researchers and industries globally.

The chemical structure of 5-Bromoindole features an indole ring system substituted with a bromine atom at the 5-position. The indole moiety is a prevalent scaffold in biologically active molecules, contributing to its utility in medicinal chemistry. The bromine atom, being an excellent leaving group, facilitates a range of synthetic transformations. Key reactions include palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura coupling (reaction with organoboron compounds), Heck coupling (reaction with alkenes), and Sonogashira coupling (reaction with terminal alkynes). These reactions allow for the facile introduction of diverse carbon-based substituents onto the indole core, leading to complex molecular architectures.

The presence of the bromine atom also enables nucleophilic aromatic substitution under specific conditions, although cross-coupling is more commonly employed. Furthermore, the nitrogen atom of the indole ring can be functionalized, allowing for N-alkylation or N-acylation, further expanding the synthetic possibilities. The compound's physical properties, such as its appearance as a White to almost white crystalline powder and a melting point between 88-93°C, make it relatively easy to handle and purify. Its high purity, typically ≥99.00%, is a testament to our rigorous manufacturing standards, ensuring reliable performance in downstream syntheses.

The primary application of 5-Bromoindole is as a pharmaceutical intermediate. It is integral to the synthesis of drugs targeting a wide array of conditions, including various cancers, inflammatory diseases, and neurological disorders. Its utility extends to the development of novel research chemicals and probes used in biological studies. For industries looking to buy 5-bromoindole, partnering with a reliable manufacturer in China like NINGBO INNO PHARMCHEM CO.,LTD. is a strategic choice. We ensure consistent product quality and availability, coupled with competitive pricing for bulk purchases. We invite you to contact us for a quote and explore how our high-quality 5-Bromoindole can support your synthetic endeavors.