Understanding the inherent chemical properties of an intermediate is fundamental for chemists looking to leverage its potential in synthesis. 5-Fluoro-2-methoxypyridine (CAS: 51173-04-7) is a fascinating molecule whose structure dictates its reactivity and broad applicability in various chemical fields, most notably in pharmaceutical and fine chemical industries.

Chemically, 5-Fluoro-2-methoxypyridine is characterized by its pyridine ring, a six-membered aromatic heterocycle containing one nitrogen atom. The presence of a fluorine atom at the 5-position and a methoxy group at the 2-position imparts specific electronic and steric effects. The fluorine atom is known for its electronegativity, which can influence the electron density of the ring and affect reaction pathways, often enhancing metabolic stability and lipophilicity in derived compounds. The methoxy group, an electron-donating group, can also influence the reactivity of the pyridine ring, particularly in electrophilic aromatic substitution reactions, although pyridine itself is generally less reactive towards these than benzene.

Its physical properties, such as a melting point and boiling point, are key for handling and reaction design. While specific melting point data varies, it is typically described as a white crystalline powder. The boiling point of approximately 144.8°C at 760 mmHg indicates it is a relatively volatile compound under standard conditions, requiring appropriate storage and handling. Its density is approximately 1.146 g/cm³.

The applications of 5-Fluoro-2-methoxypyridine are diverse and significant. In medicinal chemistry, it serves as a crucial intermediate in the synthesis of numerous drug candidates. Its pyridine core is a common feature in many pharmaceuticals, and the fluorine substituent can improve pharmacokinetic profiles. For example, it is used in the preparation of kinase inhibitors and other therapeutic agents. The compound’s ability to undergo various functionalization reactions makes it a versatile tool for creating complex molecular architectures. Researchers often buy 5-Fluoro-2-methoxypyridine to introduce this specific fluorinated pyridine moiety into larger molecules.

As a leading chemical supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality 5-Fluoro-2-methoxypyridine to support these vital research and development efforts. We ensure our product meets rigorous purity standards, allowing scientists to confidently utilize it in their synthetic pathways. Whether you are developing new pharmaceuticals, advanced materials, or fine chemicals, understanding the properties and applications of 5-Fluoro-2-methoxypyridine is key to unlocking its full potential. Connect with us to source this essential intermediate for your next project.