In the realm of fine chemicals, understanding the precise properties and reactivity of a compound is paramount for its successful application in synthesis. 2-Chloro-3-methoxypyridine (CAS: 52605-96-6) is a prime example of a critical intermediate whose chemical profile dictates its utility across various demanding industries. For researchers, formulators, and procurement specialists, a clear grasp of its characteristics is essential for making informed sourcing decisions. We, as a dedicated manufacturer and supplier, provide comprehensive information to support your needs.

Chemical Profile: 2-Chloro-3-methoxypyridine (CAS: 52605-96-6)

This compound is characterized by its molecular formula C6H6ClNO and a molecular weight of 143.57 g/mol. It typically presents as a white to off-white crystalline powder with a purity of ≥98.0%. The presence of a chlorine atom at the 2-position and a methoxy group at the 3-position on the pyridine ring are key to its chemical behavior. The chlorine atom acts as a leaving group, making the molecule susceptible to nucleophilic aromatic substitution (SNAr) and a participant in various transition-metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings.

The methoxy group, on the other hand, influences the electronic distribution within the pyridine ring and can direct or modify the regioselectivity of reactions. This dual functionality makes 2-Chloro-3-methoxypyridine an exceptionally versatile building block in organic synthesis. Its melting point and solubility characteristics are also important considerations for process chemists when designing reaction conditions and purification strategies.

Key Applications Driven by Reactivity

The well-defined reactivity of 2-Chloro-3-methoxypyridine underpins its extensive use as an intermediate:

  • Pharmaceutical Industry: It is instrumental in the synthesis of various APIs, particularly those requiring a substituted pyridine core. Its use in developing anti-inflammatory and antimicrobial agents highlights its importance in medicinal chemistry. Researchers aiming to buy 2-Chloro-3-methoxypyridine for drug discovery benefit from its predictable reactivity.
  • Agrochemical Sector: This compound is a precursor for synthesizing active ingredients in herbicides and fungicides, contributing to enhanced crop protection and yield. Its consistent quality ensures reliable performance in agrochemical formulations.
  • Materials Science: Derivatives of 2-Chloro-3-methoxypyridine can be utilized in the creation of advanced materials, leveraging the unique properties imparted by the pyridine ring and its substituents.

When looking to purchase this chemical, understanding its CAS number (52605-96-6) is crucial for accurate identification and sourcing. It is advisable to secure supply from a reputable manufacturer who can guarantee the specified purity and provide detailed technical data.

Sourcing Strategies and Pricing Considerations

For procurement professionals, identifying a reliable 2-Chloro-3-methoxypyridine supplier in China is key to maintaining cost-effectiveness and supply chain security. Direct engagement with manufacturers allows for better negotiation on price and ensures access to technical expertise. Companies often seek suppliers who can provide not only the chemical itself but also support in terms of documentation, such as Certificates of Analysis (COA) and Safety Data Sheets (SDS). Obtaining a quote for bulk quantities is a standard practice to manage project budgets effectively.

In conclusion, 2-Chloro-3-methoxypyridine is more than just a chemical compound; it is a gateway to innovation. Its well-characterized chemical properties and broad applicability make it an indispensable tool for synthetic chemists. By understanding its profile and partnering with reliable suppliers, researchers and manufacturers can effectively leverage this intermediate for groundbreaking advancements.