Fmoc-D-2-Methylphenylalanine (CAS 352351-63-4) is a highly valued compound in the fields of synthetic organic chemistry, particularly within peptide synthesis and pharmaceutical research. Its chemical structure, featuring the Fmoc protecting group and a methyl-substituted phenylalanine moiety, endows it with specific properties that are crucial for advanced applications. Understanding these characteristics is key for scientists and chemists looking to utilize this building block effectively.

Chemically, Fmoc-D-2-Methylphenylalanine presents as a white to off-white solid or powder. Its molecular formula is C25H23NO4, with a molecular weight of approximately 401.45 g/mol. The melting point typically falls within the range of 110-116°C, indicating its solid nature under standard laboratory conditions. The presence of the bulky Fmoc group on the amino terminus and the methyl group on the phenyl ring significantly influences its solubility and reactivity during synthesis.

The Fmoc group's lability to mild basic conditions (like piperidine) is a cornerstone of its utility, allowing for selective deprotection and subsequent coupling with other amino acids or reagents. This characteristic is fundamental to the efficiency of Solid-Phase Peptide Synthesis (SPPS). The D-configuration of the amino acid is also important for researchers aiming to incorporate non-natural amino acids into peptide sequences, potentially enhancing their stability against enzymatic degradation or altering their biological activity.

The applications of Fmoc-D-2-Methylphenylalanine are primarily concentrated in sophisticated research areas. It serves as a vital building block for synthesizing peptides with unique conformational properties or enhanced stability. This makes it invaluable in drug discovery, where modified peptides can lead to more effective therapeutics with improved pharmacokinetic profiles. Researchers in medicinal chemistry often buy this compound to explore structure-activity relationships (SAR) and design novel peptidomimetics.

Furthermore, its use extends to biochemical research, where scientists may employ it to study protein-protein interactions or to synthesize peptide-based probes. For those looking to purchase this intermediate, ensuring a high purity level (e.g., ≥97%) and reliable supply from a reputable manufacturer is essential for achieving reproducible experimental results. The competitive pricing and availability from specialized chemical suppliers facilitate its integration into diverse research projects.