Methyl D-(-)-4-hydroxy-phenylglycinate, identified by its CAS number 37763-23-8, is a fascinating organic compound that serves as a valuable building block in various chemical synthesis pathways. Its unique chemical structure, featuring an ester group, an amino group, and a hydroxyl-substituted phenyl ring, endows it with versatile reactivity and desirable properties for pharmaceutical and fine chemical applications.

Chemically, this compound is a methyl ester of D-(-)-4-hydroxyphenylglycine. Its molecular formula is C9H11NO3, and it has a molecular weight of approximately 181.19 g/mol. Typically appearing as a white to off-white crystalline solid, it exhibits solubility in polar organic solvents such as methanol and ethanol, and limited solubility in water. The presence of the chiral center at the alpha-carbon atom, specifically in the D-(-) configuration, is particularly significant for its use in synthesizing stereospecific molecules. The hydroxyl group on the phenyl ring can also participate in various reactions, such as etherification or esterification, further expanding its utility.

The primary application for Methyl D-(-)-4-hydroxy-phenylglycinate is as a crucial intermediate in the synthesis of amoxicillin, a widely used antibiotic. Its structure provides the necessary side chain that, when coupled with the core beta-lactam nucleus, yields the effective amoxicillin molecule. Beyond amoxicillin, this compound can be employed in the synthesis of other pharmaceutical agents and complex organic molecules where a functionalized chiral phenylglycine unit is required. Researchers often seek this material for custom synthesis projects, exploring new chemical entities and optimizing existing synthetic routes.

For those in the chemical industry looking to purchase Methyl D-(-)-4-hydroxy-phenylglycinate, it is imperative to source from reputable manufacturers that guarantee high purity and consistent quality. Suppliers who can provide detailed technical specifications, including NMR and HPLC data, are invaluable for R&D and production planning. Whether you are a researcher exploring novel synthetic pathways or a manufacturer requiring bulk quantities of this essential intermediate, ensuring a stable supply from a trusted supplier like NINGBO INNO PHARMCHEM CO.,LTD. is key to successful outcomes.