Understanding the detailed chemical and physical properties of pharmaceutical intermediates is essential for their effective utilization in drug synthesis. N-Benzyl-1-(4-methoxyphenyl)propan-2-amine (CAS: 43229-65-8) is a compound of significant interest due to its role as a precursor in the pharmaceutical industry, particularly for CNS-active drugs. This article delves into its properties, synthesis, and primary applications, offering insights for researchers and procurement professionals.

Physicochemical Profile of N-Benzyl-1-(4-methoxyphenyl)propan-2-amine

N-Benzyl-1-(4-methoxyphenyl)propan-2-amine, also known by synonyms such as N-benzyl-1-(4-methoxyphenyl)propan-2-amine, is characterized by its molecular formula C17H21NO and a molecular weight of approximately 255.36 g/mol. Commonly supplied as a pale yellow to yellow liquid, it possesses a density of around 1.024 g/cm³. Its boiling point is noted at 377.8 °C at 760 mmHg, with a flash point of 160.3 °C. Stability under normal temperatures and pressures is a key attribute. While it is soluble in organic solvents like ethanol and dichloromethane, it remains insoluble in water, typical for many organic intermediates.

Synthesis and Manufacturing Insights

The synthesis of N-Benzyl-1-(4-methoxyphenyl)propan-2-amine often involves reductive amination processes. A common route involves reacting 1-(4-methoxyphenyl)propan-2-one with benzylamine in the presence of a catalyst, such as platinum on carbon, under a hydrogen atmosphere. The product is then isolated and purified to achieve the required high purity, often exceeding 95%. As a manufacturer, ensuring consistent quality through controlled synthesis conditions and effective purification methods is paramount. We provide this intermediate with guaranteed purity, suitable for demanding pharmaceutical applications.

Key Applications in Pharmaceutical Synthesis

The primary application of N-Benzyl-1-(4-methoxyphenyl)propan-2-amine lies in its utility as a critical intermediate for the synthesis of various pharmaceutical compounds. It is notably recognized for its role in the production of Formoterol Fumarate, a long-acting beta-agonist used to treat asthma and COPD. Beyond this, its structural features make it a valuable starting material for other CNS-active pharmaceuticals and specialty chemicals, supporting research and development in areas such as psychotropic medications and neurochemical probes. Pharmaceutical companies seeking reliable suppliers for this intermediate can benefit from our commitment to quality and consistent supply from our China-based facilities.

Quality Standards and Handling Recommendations

We supply N-Benzyl-1-(4-methoxyphenyl)propan-2-amine with a minimum purity of 95%, adhering to strict quality control protocols. For optimal long-term storage and to maintain its integrity, it is recommended to store the compound in a refrigerator, ideally under an inert atmosphere, to prevent degradation. Proper handling procedures should always be followed, referencing the material's safety data sheet (SDS).

In conclusion, N-Benzyl-1-(4-methoxyphenyl)propan-2-amine is a versatile and important intermediate for the pharmaceutical industry. Its well-defined chemical properties and crucial role in synthesizing therapeutic agents make it a sought-after compound. Partnering with experienced manufacturers ensures access to a reliable supply of this high-purity chemical.