In the intricate world of pharmaceutical synthesis, understanding the properties of each chemical intermediate is crucial for successful development and manufacturing. Rivaroxaban Intermediate Hydrochloride (CAS 898543-06-1) is one such compound that plays a pivotal role in the production of a significant therapeutic agent. This article explores its key chemical characteristics, its function as an intermediate, and its broader industrial relevance, providing valuable insights for R&D scientists and procurement specialists.

Chemical Identity and Properties

Rivaroxaban Intermediate Hydrochloride, with the CAS number 898543-06-1, is chemically known as 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholin-3-one hydrochloride. It is a crystalline solid, typically appearing as a white or off-white powder. Its molecular formula is C14H17N3O4·HCl, and its molecular weight is approximately 327.77 g/mol. The hydrochloride salt form enhances its solubility in polar solvents, which is advantageous for its use in various reaction media. The compound features several key functional groups: a morpholinone ring, an oxazolidinone ring, and an aminomethyl group. The (5S) stereochemistry is critical for its specific biological activity and its role in the synthesis of chiral drug molecules.

Role as a Pharmaceutical Intermediate

The primary and most critical application of Rivaroxaban Intermediate Hydrochloride is its use as a key intermediate in the synthesis of Rivaroxaban. Rivaroxaban is a blockbuster anticoagulant drug that inhibits Factor Xa, a critical enzyme in the coagulation cascade. The synthesis of Rivaroxaban is a complex, multi-step process that requires precisely structured precursors. Rivaroxaban Intermediate Hydrochloride provides a substantial portion of the final Rivaroxaban molecule, specifically the core structure that interacts with the target enzyme. Manufacturers rely on the consistent quality and purity of this intermediate to ensure the efficiency of subsequent synthesis steps and the ultimate purity of the final API.

Industrial Significance and Sourcing Considerations

The industrial significance of this intermediate is directly tied to the global demand for Rivaroxaban. As Rivaroxaban remains a widely prescribed medication for preventing and treating blood clots, the demand for its intermediates remains robust. Pharmaceutical companies must secure a reliable supply chain for Rivaroxaban Intermediate Hydrochloride. When looking to buy, it is essential to source from reputable manufacturers who can guarantee:

  • High Purity: Essential for meeting stringent pharmaceutical regulations.
  • Consistent Quality: Ensuring batch-to-batch uniformity.
  • Scalable Production: The capacity to meet large-volume demands.
  • Competitive Pricing: Cost-effectiveness for API production.

Suppliers in China are often a preferred source due to their manufacturing capacity and competitive pricing. However, thorough vetting of any potential manufacturer or supplier is recommended to ensure compliance with international quality standards.

Beyond Synthesis: Potential Research Applications

While its primary role is as a synthetic precursor, compounds with similar structures can sometimes be explored for related research purposes in medicinal chemistry. Investigating structural analogues or studying specific functional groups for their potential interaction with biological targets could be avenues for further scientific inquiry, although its main industrial value remains in Rivaroxaban production.

In summary, Rivaroxaban Intermediate Hydrochloride (CAS 898543-06-1) is a vital fine chemical, distinguished by its specific structure and high purity. Its role as a cornerstone in the synthesis of Rivaroxaban makes it indispensable for the pharmaceutical industry. Sourcing this intermediate from reliable manufacturers who prioritize quality and consistency is paramount for the continued availability of this critical anticoagulant therapy.