For scientists and procurement professionals involved in chemical synthesis, a thorough understanding of the properties of key building blocks is essential. Boc-L-Propargylglycine (CAS 63039-48-5) is a notable amino acid derivative, recognized for its utility in peptide synthesis and various research applications. This article provides a detailed look at its chemical characteristics and why it is a crucial compound to source from a reputable manufacturer.

The chemical identity of Boc-L-Propargylglycine is defined by its structure: an L-alanine backbone where one hydrogen atom on the beta-carbon is replaced by an ethynyl group (-CH2-C≡CH), and the alpha-amino group is protected by a tert-butyloxycarbonyl (Boc) group. Its molecular formula is C10H15NO4, and it has a molecular weight of approximately 213.23 g/mol. Commonly referred to by synonyms such as N-Boc-L-propargylglycine or Boc-Pra-OH, this compound is typically presented as a white powder, indicative of its purity and solid state at room temperature.

The Boc group is a cornerstone of its utility. This acid-labile protecting group shields the amino terminus of the amino acid during peptide bond formation. Its advantage lies in its selective removal using mild acidic conditions (e.g., trifluoroacetic acid or HCl), which typically does not affect other common protecting groups or the peptide backbone itself. This selectivity is critical for the stepwise assembly of peptides, ensuring controlled chain growth.

The propargyl group (–CH2–C≡CH) provides another layer of functionality. The terminal alkyne is a highly reactive functional group, particularly amenable to cycloaddition reactions. The most prominent among these is the copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC), a prime example of 'click chemistry.' This reaction allows for the efficient and specific conjugation of Boc-L-Propargylglycine-containing peptides to other molecules, such as azide-functionalized probes, biomolecules, or solid supports. This capability is invaluable in areas like bioconjugation, drug delivery systems, and the creation of functionalized materials.

When considering where to buy Boc-L-Propargylglycine, selecting a reliable supplier in China like us ensures access to a product with confirmed purity and consistent quality. We provide detailed specifications, including purity levels (often ≥99% by HPLC) and chiral purity, which are critical for demanding applications in research and development. Understanding these chemical properties allows scientists to better integrate this compound into their synthetic pathways.

The applications of Boc-L-Propargylglycine are diverse, ranging from fundamental peptide synthesis in academic research to its use in drug discovery programs and the development of novel materials. Its ability to introduce both a protected amino acid and a reactive alkyne handle makes it a highly versatile tool. For procurement managers and researchers, understanding these chemical properties helps in making informed decisions about sourcing and application.

In summary, Boc-L-Propargylglycine is a sophisticated chemical intermediate whose properties make it indispensable for modern synthetic chemistry. Its Boc protection and propargyl functionality offer significant advantages for peptide synthesis and beyond. We invite you to inquire about our high-quality Boc-L-Propargylglycine and discover the value we bring as a dedicated chemical supplier. We offer competitive price options and are ready to meet your specific requirements.