For researchers and development chemists, a thorough understanding of a chemical intermediate's properties is foundational to successful synthesis. Ethyl 4-Chloroacetoacetate (CAS 638-07-3) is one such compound, whose specific characteristics dictate its utility and handling in various laboratory and industrial applications. As a premier chemical supplier, NINGBO INNO PHARMCHEM CO., LTD. is committed to providing high-quality intermediates with detailed property insights.

Physical and Chemical Characteristics

Ethyl 4-Chloroacetoacetate is primarily known as a liquid, typically presenting as colorless to a pale yellow hue. Its molecular formula is C6H9ClO3, and it has a molecular weight of approximately 164.59 g/mol. The presence of a reactive chloro group (ClCH2-) adjacent to a carbonyl group, and a further carbonyl group within the ester chain (-COCH2CO2C2H5), imbues this molecule with significant chemical versatility. This dual functionality makes it a prime candidate for a wide range of organic reactions, enabling the synthesis of more complex structures.

Reactivity and Synthesis Utility

The reactivity of Ethyl 4-Chloroacetoacetate stems from its active methylene group and the electrophilic nature of its carbonyl carbons. This makes it an excellent substrate for nucleophilic substitution reactions, condensation reactions, and cyclization processes. It is widely utilized as a key intermediate in the synthesis of:

  • Heterocyclic Compounds: Essential for forming ring structures like pyridines, pyrimidines, and quinolones, which are prevalent in pharmaceuticals and agrochemicals.
  • Pharmaceutical Ingredients: Serves as a crucial precursor in the synthesis of various APIs, contributing to the development of drugs across multiple therapeutic classes.
  • Agrochemicals: Forms the basis for active ingredients in herbicides, fungicides, and other crop protection agents.

When considering where to buy Ethyl 4-Chloroacetoacetate, chemists look for manufacturers who guarantee consistent reactivity and purity, typically ≥97% (GC). This ensures that the expected chemical transformations proceed efficiently and with high yields.

Stability and Storage Considerations

Proper storage is critical for maintaining the quality and integrity of Ethyl 4-Chloroacetoacetate. The recommended storage conditions are typically in a cool, dry place, often between 2-8°C, and protected from moisture and light. Storing it under an inert gas atmosphere is also sometimes advised for extended preservation. As a chemical manufacturer, understanding and communicating these storage needs is part of our commitment to customer success. Incorrect storage can lead to degradation, affecting its reactivity and purity.

Safety and Handling

While detailed safety information is available in its MSDS, general precautions for handling Ethyl 4-Chloroacetoacetate include using it in a well-ventilated area or fume hood, and wearing appropriate personal protective equipment (PPE) such as gloves, eye protection, and protective clothing. Its potential for skin and eye irritation necessitates careful handling.

In summary, the chemical properties of Ethyl 4-Chloroacetoacetate make it an indispensable intermediate for researchers and industrial chemists. Its reactivity, stability under proper conditions, and broad synthetic applicability solidify its importance. For those seeking to purchase Ethyl 4-Chloroacetoacetate, partnering with a reputable supplier in China like NINGBO INNO PHARMCHEM CO., LTD. ensures access to a high-quality product backed by essential technical knowledge.