In the chemical manufacturing industry, a thorough understanding of a compound's properties is fundamental to its safe and effective utilization. 3-Chloro-5-fluoropyridine, identified by CAS number 514797-99-0, is a valuable intermediate widely employed in pharmaceutical and fine chemical synthesis. This article provides a detailed overview of its key chemical properties, along with essential handling, storage, and safety guidelines crucial for industrial environments. For companies looking to purchase this compound, grasping these aspects ensures operational efficiency and safety.

Understanding the Chemical Profile

3-Chloro-5-fluoropyridine is a heterocyclic organic compound with the molecular formula C5H3ClFN and a molecular weight of approximately 131.54 g/mol. It is typically described as a yellow liquid with a density around 1.3 g/cm³. Key physical parameters include:

  • Boiling Point: Approximately 126.1 °C at 760 mmHg. This indicates moderate volatility and influences process design for distillation or reaction temperature control.
  • Flash Point: Around 51.9 °C. This value signifies that the compound is a flammable liquid, requiring appropriate fire safety measures during handling and storage.
  • Refractive Index: Measured at approximately 1.503, this property is relevant for quality control and analytical identification.
  • Purity: Industrial grades commonly meet or exceed 98.0% purity, which is critical for its role as a pharmaceutical intermediate where impurities can significantly impact reaction outcomes and final product quality.

Safe Handling and Storage Practices

Given its flammable nature and potential for irritation, safe handling practices are paramount when working with 3-Chloro-5-fluoropyridine. Procurement specialists and laboratory personnel should adhere to the following guidelines:

  • Personal Protective Equipment (PPE): Always use appropriate PPE, including chemical-resistant gloves (e.g., nitrile or neoprene), safety goggles or a face shield, and protective clothing to prevent skin and eye contact.
  • Ventilation: Handle the compound in a well-ventilated area, preferably under a fume hood, to minimize exposure to vapors.
  • Ignition Sources: Keep away from heat, sparks, open flames, and hot surfaces. Ensure all electrical equipment is properly grounded to prevent static discharge.
  • Storage Conditions: Store 3-Chloro-5-fluoropyridine in tightly closed containers in a cool, dry, and well-ventilated area, away from incompatible materials. Recommended storage temperatures are typically at room temperature or as specified by the manufacturer.
  • Incompatibilities: Avoid contact with strong oxidizing agents, strong acids, and strong bases, which could lead to hazardous reactions.

Industrial Significance and Procurement Considerations

As a manufacturer and supplier, we understand the importance of providing detailed chemical information to our clients. When you choose to buy 3-Chloro-5-fluoropyridine from us, you are selecting a product that meets high industry standards for purity and consistency. For procurement specialists, ensuring that the manufacturer provides comprehensive SDS and product specifications is essential for risk assessment and safe operational planning. The consistent quality of this intermediate is key for the reliable synthesis of pharmaceuticals and fine chemicals. Therefore, partnering with a reputable supplier who prioritizes safety and product integrity is a critical business decision.

By understanding and implementing these chemical properties and safety guidelines, industrial users can effectively and safely utilize 3-Chloro-5-fluoropyridine, maximizing its benefits in their synthesis processes.