For chemists and researchers engaged in organic synthesis, a thorough understanding of chemical properties and safe handling procedures for key intermediates is essential. 4-Chloro-2-fluorobenzonitrile (CAS 57381-51-8) is one such compound, valued for its specific characteristics and application potential. This article delves into its physical and chemical attributes, providing insights for R&D scientists and laboratory professionals.

Understanding the Chemistry: Properties of 4-Chloro-2-fluorobenzonitrile

4-Chloro-2-fluorobenzonitrile is an aromatic compound with the molecular formula C7H3ClFN. Its structure features a benzene ring with a nitrile group, a chlorine atom at the para position, and a fluorine atom at the ortho position. Key physical and chemical properties include:

  • Appearance: Typically a white to light yellow powder or fused solid.
  • Assay Purity: Generally specified as u226598.0%, ensuring high quality for synthesis.
  • Molecular Weight: Approximately 155.56 g/mol.
  • Melting Point: Ranges from 58-61 °C, indicating a relatively stable solid form at room temperature.
  • Boiling Point: Around 207.3 °C at 760 mmHg, suggesting it is a high-boiling point liquid when heated.
  • Solubility: Insoluble in water but soluble in common organic solvents like ethanol and acetone.

These properties make it a versatile reagent for various chemical reactions. When you need to buy this compound, always check the specific datasheet for precise values.

Safe Handling and Storage Recommendations

As with many specialty chemicals, safe handling practices are paramount. It is advised that 4-Chloro-2-fluorobenzonitrile be handled in a well-ventilated area, preferably under a fume hood. Personal protective equipment (PPE) such as gloves, safety glasses, and lab coats should be worn. Inhalation, ingestion, or skin contact should be avoided. Store the compound in a cool, dry place, away from incompatible materials, to maintain its stability and prevent degradation. Consulting the Material Safety Data Sheet (MSDS) from your supplier is crucial for detailed safety protocols.

Procuring High-Quality Intermediates

For researchers and chemists looking to source 4-Chloro-2-fluorobenzonitrile, identifying a reliable manufacturer and supplier is key. Companies that provide comprehensive technical documentation and maintain high purity standards ensure that your synthetic processes are reliable. Whether you are looking for small quantities for R&D or larger batches for production, obtaining a competitive price from a trusted source in China is often achievable through direct inquiry.