4-Iodophenylacetic acid (CAS 1798-06-7) is a chemical compound notable for its distinct physical and chemical properties, which dictate its behavior in various reactions and its handling requirements. Understanding these characteristics is fundamental for its effective and safe utilization in laboratory and industrial settings.

Physically, 4-Iodophenylacetic acid typically presents as a white to off-white powder or crystalline solid. Its melting point is generally reported in the range of 130-140°C, indicating a relatively stable solid form at room temperature. Chemically, it possesses two key functional groups: an iodine atom and a carboxylic acid. The iodine atom, situated at the para position on the phenyl ring, is electronegative and can influence the electron density of the aromatic system. More importantly, it serves as a good leaving group in nucleophilic substitution and cross-coupling reactions, such as the Suzuki coupling, making it a valuable intermediate for C-C bond formation. The carboxylic acid group (-COOH) imparts acidic properties to the molecule, allowing it to undergo reactions like esterification, amidation, and salt formation. Its solubility is generally poor in water but good in common organic solvents.


Safety and handling are critical aspects when working with any chemical, and 4-Iodophenylacetic acid is no exception. While specific hazard statements may vary, compounds with similar structures can be irritating to the skin, eyes, and respiratory tract. Therefore, it is essential to consult the Safety Data Sheet (SDS) provided by the supplier, such as NINGBO INNO PHARMCHEM CO.,LTD., before use. Standard laboratory practices, including wearing appropriate personal protective equipment (PPE) like gloves, safety glasses, and a lab coat, are crucial. Work should ideally be conducted in a well-ventilated area or a fume hood. Recommended storage conditions often include keeping the container tightly closed in a cool, dry place, away from light, as it can be light-sensitive. Adhering to these guidelines ensures the safety of personnel and the integrity of the compound.