For chemists engaged in intricate synthesis, a thorough understanding of reagent properties and handling is fundamental to success. 9-Fluorenylmethyl Chloroformate (Fmoc-Cl), identified by CAS number 28920-43-6, is a potent reagent whose effective utilization relies on knowledge of its chemical behavior, stability, and safety protocols. As a dedicated manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality Fmoc-Cl and emphasizes the importance of proper handling to maintain product integrity and ensure safe laboratory practices.

Key Chemical Properties of Fmoc-Cl

Fmoc-Cl is characterized by its ability to react with nucleophilic species, primarily amines, to introduce the Fmoc protecting group. Its key chemical properties and characteristics include:

  • Molecular Formula & Weight: C15H11ClO2, with a molecular weight of approximately 258.70 g/mol.
  • Appearance: Typically presents as an off-white to white crystalline powder.
  • Reactivity: It readily reacts with amine groups under mild conditions to form stable carbamates (Fmoc-protected amines). This reactivity is the basis for its use in peptide synthesis and other derivatization applications.
  • Solubility: Fmoc-Cl is soluble in many common organic solvents such as dichloromethane (DCM), tetrahydrofuran (THF), and dimethylformamide (DMF), which are frequently used in organic synthesis.
  • Moisture Sensitivity: Like many chloroformates, Fmoc-Cl can be sensitive to moisture, potentially hydrolyzing to release HCl and the corresponding alcohol (9-fluorenylmethanol), which can impact its efficacy.

Essential Handling and Storage Guidelines

To preserve the quality of 9-fluorenylmethyl chloroformate and ensure safe laboratory operations, adherence to proper handling and storage protocols is crucial:

  • Storage Temperature: Recommended storage temperatures often range from 2–8 °C to maintain optimal stability and prevent degradation. Storing under inert gas is also advised, especially for long-term storage.
  • Container Integrity: Always keep the container tightly closed when not in use to prevent moisture ingress and contamination.
  • Handling Precautions: Handle with care in a well-ventilated area, preferably within a fume hood. Avoid inhalation of dust or vapors and prevent contact with skin and eyes. Appropriate personal protective equipment (PPE), including gloves, safety glasses, and lab coats, should always be worn.
  • Inert Atmosphere: For maximum longevity and reactivity, especially in bulk storage, keeping the material under an inert atmosphere (e.g., nitrogen or argon) is recommended.
  • Cross-Contamination: Ensure that the reagent is not exposed to incompatible materials or cross-contaminated with other chemicals.

Why Choose Our Fmoc-Cl?

As a leading Fmoc-Cl supplier, NINGBO INNO PHARMCHEM CO.,LTD. ensures that our product is manufactured to high standards of purity and stability. We provide comprehensive documentation, including Safety Data Sheets (SDS) and Certificates of Analysis (CoA), to assist our clients in safe and effective use. When you buy 9-fluorenylmethyl chloroformate from us, you are assured of a product that has been carefully manufactured and packaged to maintain its integrity.

By understanding and implementing these guidelines, researchers and manufacturers can maximize the performance of Fmoc-Cl in their synthetic processes. For reliable sourcing and expert advice, contact us to discuss your requirements for this vital chemical intermediate.