In the realm of advanced organic synthesis, particularly for peptide research, understanding the precise chemical properties and handling protocols of key reagents is fundamental. Fmoc-Dab(Boc)-OH (CAS: 125238-99-5), a protected derivative of L-2,4-diaminobutyric acid, is a prime example of such a critical compound. This article aims to demystify its chemical attributes, including molecular structure, stability, and recommended handling procedures, offering valuable information for procurement managers and research scientists seeking to buy this essential intermediate from a reliable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD.

Chemical Profile of Fmoc-Dab(Boc)-OH

Fmoc-Dab(Boc)-OH is characterized by its molecular formula C24H28N2O6 and a molecular weight of approximately 440.49 g/mol. The presence of the Fmoc group on the alpha-amino terminus provides acid-labile deprotection, commonly achieved with reagents like piperidine, a standard step in SPPS. Simultaneously, the Boc group on the gamma-amino terminus offers orthogonal protection, being cleaved under acidic conditions (e.g., trifluoroacetic acid). This orthogonal protection strategy is what makes Fmoc-Dab(Boc)-OH exceptionally valuable, allowing for selective manipulation of the amino groups during peptide assembly.

The compound typically appears as a white to off-white powder. Its solubility is generally limited in water but it dissolves well in organic solvents commonly used in peptide synthesis, such as Dimethylformamide (DMF) and Dichloromethane (DCM). Understanding these solubility characteristics is crucial for preparing reaction solutions and ensuring efficient coupling reactions.

Handling and Storage Recommendations for Optimal Performance

Proper handling and storage are vital to maintain the integrity and reactivity of Fmoc-Dab(Boc)-OH. As a fine chemical intermediate, it should be protected from moisture, light, and elevated temperatures. Most suppliers, including NINGBO INNO PHARMCHEM CO.,LTD., recommend storing the compound in a tightly sealed container in a cool, dry place, often under refrigeration (2-8°C) to prevent degradation. When handling the powder, it is essential to:

  • Use appropriate personal protective equipment (PPE): This includes gloves, safety glasses, and a lab coat to avoid skin or eye contact.
  • Work in a well-ventilated area or fume hood: Minimize inhalation of fine particles, as some organic compounds can be respiratory irritants.
  • Avoid cross-contamination: Use clean spatulas and equipment when weighing or transferring the material.

Procurement from NINGBO INNO PHARMCHEM CO.,LTD.

For researchers and purchasing departments, identifying a dependable Fmoc-Dab(Boc)-OH supplier is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality chemical intermediates, backed by comprehensive documentation and customer support. When you choose to buy Fmoc-Dab(Boc)-OH from us, you are assured of a product that meets stringent quality specifications, crucial for successful peptide synthesis. We offer competitive pricing and flexible packaging options to meet diverse research needs. Our expertise as a manufacturer ensures a consistent and reliable supply chain, making us an ideal partner for your ongoing projects.

By understanding and adhering to these chemical properties and handling guidelines, and by partnering with a trusted supplier like NINGBO INNO PHARMCHEM CO.,LTD., you can maximize the efficiency and success of your peptide synthesis endeavors.