Understanding the intricate chemical and physical properties of pharmaceutical intermediates is fundamental for R&D scientists and process engineers. For 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one (CAS: 1218-69-5), a critical intermediate for Deferasirox, a detailed examination of its characteristics is essential for successful synthesis and scale-up. This knowledge empowers buyers to make informed decisions when sourcing from manufacturers.

The compound, chemically known as 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one, presents as a white to yellow crystalline powder. Its molecular formula is C14H9NO3, with a molecular weight of approximately 239.23 g/mol. Key physical properties that influence handling and storage include its melting point, typically in the range of 204.0 to 208.0 °C. While boiling point and density are also important, predicted values are often available for these. For effective use, understanding its solubility in various solvents, such as chloroform, DMSO, and ethyl acetate, is also critical for formulation and reaction design. Researchers often seek this specific data when planning experimental procedures.

The manufacturing process for 1218-69-5 involves specific chemical reactions, often starting from raw materials like disalicylimide or related precursors. A common synthesis route involves cyclization reactions under controlled conditions, often with acid catalysts. Manufacturers pay close attention to reaction parameters such as temperature, reaction time, and purification steps to achieve the desired high purity, typically ≥98.0% assay. As a manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. ensures that each batch meets these stringent purity requirements, providing reliable material for your production needs.

When considering a purchase of this intermediate, it is vital to understand the typical specifications and quality controls employed by the supplier. A reputable manufacturer will provide comprehensive technical data, including CoA, detailing the assay, impurity profile, and other critical parameters. This information is crucial for regulatory submissions and ensuring the quality of the final Deferasirox product. If you are looking to buy this chemical, inquire about lot-specific analysis and batch traceability.

The utility of 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one is primarily as a key intermediate in the production of Deferasirox. This pharmaceutical is used to treat chronic iron overload, making the reliable supply of its precursors essential for global health. As a leading supplier and manufacturer in China, we are committed to supporting the pharmaceutical industry by providing this high-quality intermediate. We offer competitive pricing and flexible packaging options to suit your specific requirements. Contact us for a detailed quote and to discuss your procurement needs.

In summary, the chemical and physical properties of 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one (CAS: 1218-69-5) are well-defined, making it a sought-after intermediate for Deferasirox synthesis. Prospective buyers should prioritize sourcing from reliable manufacturers who guarantee high purity and consistent quality. Understanding these properties will streamline your purchasing process and ensure the success of your pharmaceutical manufacturing operations.