For chemists, researchers, and production managers in the pharmaceutical industry, a thorough understanding of the physical and chemical properties of key intermediates is fundamental. Methyl 5-chloro-3-[(2-methoxy-2-oxoethyl)sulfamoyl]-2-thiophenecarboxylate (CAS: 906522-87-0) is a prime example, serving as a crucial intermediate in the synthesis of Lornoxicam. Familiarity with its properties aids in process optimization, safety protocols, and successful procurement. As a leading manufacturer and supplier, we aim to provide clarity on these essential details.

Key Chemical Structure and Identity

The chemical name, Methyl 5-chloro-3-[(2-methoxy-2-oxoethyl)sulfamoyl]-2-thiophenecarboxylate, clearly defines its structure. It features a thiophene ring, a five-membered heterocyclic aromatic compound containing sulfur, which is substituted at various positions. The presence of a chlorine atom, a sulfamoyl group linked to a methoxycarbonylmethyl moiety, and a methyl ester group on the thiophene ring contributes to its reactivity and suitability for specific synthetic pathways. Its molecular formula is C9H10ClNO6S2, and its molecular weight is approximately 327.76 g/mol. These identifiers are critical for accurate research and sourcing.

Physical Characteristics and Handling Considerations

In terms of physical properties, this compound is typically described as a yellow crystalline powder. This appearance is a visual indicator of its solid state and purity, although definitive quality assessment relies on analytical methods. While specific density and boiling point data are provided (e.g., density around 1.5±0.1 g/cm³, boiling point around 480.4±55.0 °C at 760 mmHg), it is important to note that for many fine chemical intermediates, decomposition may occur before reaching their theoretical boiling point at atmospheric pressure. Flash point data (e.g., 244.3±31.5 °C) indicates its relative flammability and is important for safe handling and storage protocols. Its low vapor pressure (0.0±1.2 mmHg at 25°C) suggests it is not highly volatile at standard room temperatures.

Specifications for Pharmaceutical Applications

For its use in pharmaceutical synthesis, strict specifications are maintained by reputable suppliers. These typically include:

  • Assay: ≥99.0% (by HPLC), ensuring high chemical purity.
  • Max Single Impurity: ≤0.5%, critical for controlling by-product formation.
  • Total Impurities: ≤1.0%, a measure of overall purity.
  • Loss on Drying: ≤0.5%, indicating low moisture content.

These specifications underscore the compound's suitability as a reliable building block for Lornoxicam API. When you buy this intermediate, these are the quality markers to look for. Understanding these properties enables chemists and manufacturers to effectively integrate this compound into their synthetic processes, ensuring both efficiency and product integrity. As a reliable manufacturer, we provide this intermediate with detailed specifications for your R&D and production needs.