Understanding the Chemical Properties of Boc-(R)-3-Amino-4-(2-methyl-phenyl)-butyric Acid
For professionals in chemical synthesis and formulation, a thorough understanding of a compound's intrinsic properties is fundamental to its effective utilization. Boc-(R)-3-Amino-4-(2-methyl-phenyl)-butyric Acid (CAS: 269398-80-3) is one such compound that demands careful consideration of its chemical characteristics. This protected amino acid derivative, commonly presented as a white solid or powder, offers a unique combination of features that make it highly valuable in various research and industrial applications.
The defining feature of this molecule is the tert-butyloxycarbonyl (Boc) protecting group attached to the amine nitrogen. This group is renowned for its stability under a wide range of reaction conditions, including many common organic transformations such as esterification, amidation, and nucleophilic substitutions. However, it is readily and selectively removed under mild acidic conditions, such as treatment with trifluoroacetic acid (TFA) or hydrochloric acid in organic solvents. This characteristic orthogonality of the Boc group allows for precise control in multistep synthetic pathways, preventing unintended reactions at the amine site while other functional groups are manipulated.
The chirality at the alpha-carbon (R configuration) is another critical property, especially for applications in pharmaceuticals and chiral synthesis. The specific spatial arrangement of atoms around this carbon center dictates how the molecule interacts with other chiral molecules, including biological receptors and enzymes. For manufacturers and researchers who need to buy this compound, ensuring high enantiomeric purity is often a prerequisite for successful synthesis of enantiomerically pure final products.
The presence of the 2-methylphenyl group introduces steric bulk and electronic effects that can influence the molecule's reactivity and the properties of the compounds derived from it. The ortho-methyl substitution on the phenyl ring can affect the conformation of the molecule and may also impact the rate of reactions occurring at or near the phenyl ring, such as electrophilic aromatic substitution. These subtle influences are important considerations for chemists designing synthetic routes.
The physical properties, such as its form as a white solid or powder, contribute to ease of handling and weighing in laboratory and industrial settings. While precise melting point data is often application-specific or depends on purity, its solid state at room temperature is typical for such molecules. Information regarding solubility in common organic solvents is also vital for formulators and synthetic chemists. Solvents like dichloromethane, ethyl acetate, and methanol are often used for dissolving such compounds, facilitating reactions and purification processes.
For those seeking to purchase Boc-(R)-3-Amino-4-(2-methyl-phenyl)-butyric Acid, understanding these chemical properties allows for informed decision-making. A reliable manufacturer and supplier, such as NINGBO INNO PHARMCHEM CO.,LTD., will provide detailed technical specifications that elucidate these properties, enabling chemists to leverage this intermediate's full potential in their synthesis and product development endeavors. By understanding its stability, reactivity, and chirality, researchers can effectively integrate this compound into their chemical strategies.
Perspectives & Insights
Data Seeker X
“The chirality at the alpha-carbon (R configuration) is another critical property, especially for applications in pharmaceuticals and chiral synthesis.”
Chem Reader AI
“The specific spatial arrangement of atoms around this carbon center dictates how the molecule interacts with other chiral molecules, including biological receptors and enzymes.”
Agile Vision 2025
“For manufacturers and researchers who need to buy this compound, ensuring high enantiomeric purity is often a prerequisite for successful synthesis of enantiomerically pure final products.”