For chemists engaged in the design and synthesis of novel molecules, a deep understanding of the chemical properties and reactivity of intermediates is indispensable. 1H-Pyrazole-3-carbonitrile (CAS 36650-74-5) is a heterocyclic organic compound that offers a fascinating interplay of structural features leading to versatile reactivity. Its pyrazole ring, a five-membered aromatic system with two nitrogen atoms, provides a stable scaffold, while the nitrile (-C≡N) group introduces a key point for chemical modification. This article delves into the fundamental chemical aspects that make this compound a valuable asset in various synthetic endeavors.

The molecular structure of 1H-Pyrazole-3-carbonitrile, with the chemical formula C4H3N3 and a molecular weight of approximately 93.09 g/mol, is central to its reactivity. The pyrazole core is aromatic, contributing to its stability. However, the presence of two nitrogen atoms within the ring influences electron distribution and provides potential sites for coordination or protonation. The nitrile group is a strong electron-withdrawing group, which significantly affects the electronic properties of the entire molecule. This electron-withdrawing nature can activate adjacent positions on the pyrazole ring towards certain reactions and also renders the nitrile carbon susceptible to nucleophilic attack.

Key reactions involving 1H-Pyrazole-3-carbonitrile include transformations of the nitrile group. For instance, it can undergo hydrolysis to form carboxylic acids, reduction to amines, or react with organometallic reagents. The pyrazole ring itself can participate in electrophilic aromatic substitution reactions, though the activating or deactivating nature of substituents and the positions of nitrogen atoms will dictate the regioselectivity. As a leading chemical supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides this intermediate to researchers who rely on its predictable reactivity for successful synthesis. When you choose to buy from us, you are assured of materials with consistent chemical properties, enabling efficient process development.

The compound's physical properties, such as its typical appearance as a liquid or solid with a specific melting point, also play a role in its handling and application. For optimal use, understanding storage conditions, such as keeping it in a cool, dry place in a tightly closed container, is important. For chemical professionals seeking to purchase this intermediate, partnering with a reputable manufacturer in China like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to not only the material itself but also the technical support that comes with expertise in its handling and application. The consistent availability and quality of 1H-Pyrazole-3-carbonitrile make it a staple for many synthetic chemists.