In the realm of specialty chemicals, a thorough understanding of a compound's properties and associated safety measures is fundamental for its effective and responsible use. This article focuses on 4-[Chloro(difluoro)methoxy]aniline (CAS 39065-95-7), a compound recognized for its utility as a pharmaceutical intermediate and in other fine chemical applications. We will explore its key chemical characteristics, synthesis considerations, and essential safety protocols.

Chemical Profile: 4-[Chloro(difluoro)methoxy]aniline

Chemical Name: 4-[Chloro(difluoro)methoxy]aniline
CAS Number: 39065-95-7
Molecular Formula: C7H6ClF2NO
Molecular Weight: 193.58 g/mol
Appearance: Typically a white crystalline solid.

The unique structural features of 4-[Chloro(difluoro)methoxy]aniline – an aniline core substituted with a chlorodifluoromethoxy group – dictate its chemical behavior. The electron-withdrawing nature of the halogens influences the reactivity of the aromatic ring and the amine functionality. This makes it a versatile intermediate for reactions such as electrophilic aromatic substitution and various coupling reactions, critical for building complex organic molecules.

Synthesis and Purity

The synthesis of 4-[Chloro(difluoro)methoxy]aniline typically involves several steps, often starting from precursor materials and employing reactions like fluorination, nitration, and reduction. Manufacturers strive to achieve high purity levels, often exceeding 99.5%, to meet the stringent demands of the pharmaceutical industry. Quality control measures, including analytical techniques like HPLC and GC, are employed to verify purity and identify any residual impurities. When you buy 4-[Chloro(difluoro)methoxy]aniline, it is advisable to consult the supplier's specifications and Certificate of Analysis (CoA) to ensure it meets your project's requirements.

Applications and Industrial Significance

As previously discussed, the primary application of 4-[Chloro(difluoro)methoxy]aniline is as a pharmaceutical intermediate, particularly in the synthesis of anti-cancer drugs and other APIs. Its structure lends itself to creating molecules with improved pharmacokinetic properties such as enhanced metabolic stability and bioavailability. Additionally, it finds use in the agrochemical sector for producing advanced crop protection agents and in various organic synthesis pathways.

Safety, Handling, and Regulatory Information

As with any chemical, proper safety precautions must be observed when handling 4-[Chloro(difluoro)methoxy]aniline. Based on available GHS information from suppliers, this compound may cause skin and eye irritation and may cause respiratory irritation.

Recommended Safety Measures:

  • Personal Protective Equipment (PPE): Always wear appropriate PPE, including safety goggles, chemical-resistant gloves, and protective clothing.
  • Ventilation: Handle the compound in a well-ventilated area, preferably under a fume hood, to minimize inhalation exposure.
  • Handling Practices: Avoid contact with skin, eyes, and clothing. Do not ingest or inhale the material. Practice good industrial hygiene.
  • Storage: Store in a cool, dry, well-ventilated place, away from incompatible materials. Keep containers tightly closed.

Regulatory Considerations: Manufacturers and suppliers are responsible for providing Safety Data Sheets (SDS) that detail hazard information, handling procedures, first-aid measures, and disposal considerations in accordance with local and international regulations.

For professionals seeking to buy 4-[Chloro(difluoro)methoxy]aniline, understanding these properties and safety guidelines is crucial for safe and efficient laboratory and industrial use. Consulting the supplier's SDS is always the first step in responsible chemical management.