Understanding the chemical properties and synthesis routes of key intermediates is fundamental for chemists and chemical engineers involved in product development. 2-Amino-9,9-dimethylfluorene (CAS 108714-73-4) is one such compound that plays a significant role in various chemical industries, from pharmaceuticals to advanced materials. This article provides an overview of its characteristics and how it's produced, aimed at R&D scientists and chemical procurement specialists.

Chemical Profile of 2-Amino-9,9-dimethylfluorene

The compound, with the molecular formula C15H15N and a molecular weight of 209.29 g/mol, is distinguished by its fluorene core. Key properties include:

  • Appearance: Typically presents as an off-white powder.
  • Melting Point: Ranges from 166.0 to 170.0 °C, indicating a relatively stable solid at room temperature.
  • Purity: Commercial grades often boast high purity, commonly 99.5% or higher, essential for sensitive applications.
  • EINECS Number: 805-747-3.
  • Structure: Features an amino group (-NH2) on the fluorene aromatic system, offering sites for further chemical modification.

Synthesis Pathways: From Precursors to Product

The synthesis of 2-Amino-9,9-dimethylfluorene typically involves a multi-step process starting from more basic precursors. A common route involves the preparation of 9,9-dimethylfluorene, followed by nitration to introduce a nitro group, usually at the 2-position, yielding 9,9-dimethyl-2-nitrofluorene. This nitro compound is then reduced to the desired amine. For example, catalytic hydrogenation using a palladium on activated carbon catalyst in ethanol under a hydrogen atmosphere is an effective method for reducing the nitro group to an amino group. The general procedure involves reacting the nitro precursor with hydrogen gas in the presence of a catalyst, followed by filtration to remove the catalyst and subsequent purification, often via column chromatography.

Applications Driving Demand

The demand for 2-Amino-9,9-dimethylfluorene is driven by its utility as an intermediate:

  • Diagnostic Reagents: Used in synthesizing components for diagnostic kits and assays.
  • Pharmaceutical Intermediates: A building block for complex organic molecules in drug discovery.
  • Optoelectronic Materials: Incorporated into materials for OLEDs and other electronic devices due to its fluorescence and charge transport properties.

Sourcing and Purchasing Advice

For R&D scientists and procurement specialists, ensuring consistent quality and reliable supply is crucial. When looking to buy 2-Amino-9,9-dimethylfluorene, it is advisable to partner with manufacturers who provide detailed synthesis information, high purity levels, and comprehensive analytical data. As a dedicated manufacturer in China, we offer this intermediate with guaranteed quality and availability. We encourage you to contact us for detailed product information, quotes, and to discuss your purchase requirements for this important chemical intermediate.