Understanding the detailed chemical properties and synthesis pathways of key intermediates is crucial for researchers and manufacturers alike. 3-Amino-2-fluoropyridine (CAS 1597-33-7) is a prime example of such a compound, valued for its versatility in organic synthesis. As a leading chemical manufacturer in China, we provide insights into this important fluorinated pyridine derivative.

The molecular formula of 3-Amino-2-fluoropyridine is C₅H₅FN₂, with a molecular weight of 112.11 g/mol. Its physical appearance is typically described as a yellow liquid, with a boiling point of 243.2 °C at 760 mmHg and a flash point of 100.9 °C. These properties dictate its handling and storage requirements. The presence of both an amino group (-NH₂) and a fluorine atom on the pyridine ring makes it a highly reactive and versatile building block. The amino group can undergo various reactions such as acylation, alkylation, and diazotization, while the fluorine atom influences the electron density of the ring, impacting its reactivity in nucleophilic aromatic substitution or other reactions.

The synthesis of 3-Amino-2-fluoropyridine often involves multi-step processes starting from readily available pyridine derivatives. Common synthetic routes might include nitration followed by reduction to introduce the amino group, and halogenation or nucleophilic substitution to introduce the fluorine atom at the desired position. For example, starting from a suitable precursor like 2-chloropyridine or 2-hydroxypyridine, functional group interconversions can lead to the target molecule. Each step requires careful optimization of reaction conditions, catalysts, and purification methods to achieve high yields and purity, which are critical for its use as a pharmaceutical intermediate.

Safety is a paramount concern when handling any chemical. 3-Amino-2-fluoropyridine is classified with hazard statements such as H302 (Harmful if swallowed) and H319 (Causes serious eye irritation). Appropriate personal protective equipment (PPE), including gloves, safety glasses, and lab coats, should always be used. It is recommended to store the compound in a cool, dry, well-ventilated place, away from incompatible materials like strong oxidizing agents. For those looking to buy this chemical, understanding its Material Safety Data Sheet (MSDS) is essential for safe handling, storage, and disposal procedures.

As a manufacturer dedicated to providing high-quality chemical intermediates, we ensure that our 3-Amino-2-fluoropyridine production adheres to stringent quality control. We understand that consistency in chemical properties and purity is vital for our customers’ research and manufacturing processes. Whether you are involved in pharmaceutical synthesis, agrochemical development, or advanced material research, accessing reliable information about the chemical's properties and safe handling is key to successful application.

We encourage researchers and industrial chemists to consider us as their trusted supplier for 3-Amino-2-fluoropyridine. Our commitment to excellence in chemical manufacturing ensures that you receive a product that meets your exact specifications. Feel free to contact us to request a quote, obtain our latest product specifications, or discuss any specific requirements you may have for this important fluorinated building block.