Understanding the fundamental chemical properties and synthetic pathways of key intermediates is crucial for chemists and researchers involved in organic synthesis. 4-Amino-3-fluorobenzoic acid (CAS 455-87-8) is a prime example of such a compound, valued for its specific structural features and reactivity. This article explores its key chemical characteristics and common synthesis methods, offering insights for professionals looking to buy 4-amino-3-fluorobenzoic acid for their projects.

Key Chemical Properties of 4-Amino-3-fluorobenzoic Acid

4-Amino-3-fluorobenzoic acid is an aromatic organic compound with the molecular formula C7H6FNO2 and a molecular weight of 155.13 g/mol. Its structure features a benzoic acid core with an amino group (-NH2) at the para position and a fluorine atom (-F) at the meta position relative to the carboxylic acid group (-COOH). This arrangement imparts specific chemical behaviors:

  • Appearance: Typically observed as white to light yellow crystalline powder or crystals.
  • Melting Point: A characteristic melting point range of 215-218°C indicates its solid state and purity.
  • Solubility: Due to the polar amino and carboxylic acid groups, it exhibits moderate solubility in polar solvents like water and alcohols, and lower solubility in non-polar organic solvents.
  • Reactivity: The amino group can undergo acylation, alkylation, and diazotization, while the carboxylic acid group can form esters, amides, and acid halides. The fluorine atom can influence the electronic properties of the aromatic ring, affecting reactivity in electrophilic aromatic substitution.

These properties make it an attractive substrate for a variety of organic transformations.

Common Synthesis Methodologies

The synthesis of 4-Amino-3-fluorobenzoic acid typically involves multi-step processes designed to introduce the functional groups regioselectively. While specific proprietary methods may vary among manufacturers, general approaches include:

  1. Nitration followed by Reduction: Starting from a fluorinated benzoic acid derivative, nitration can be performed to introduce a nitro group, which is subsequently reduced to an amino group. For example, 3-fluorobenzoic acid might be nitrated and then reduced.
  2. Diazotization and Halogenation/Substitution: An aniline derivative with appropriate substituents could be diazotized, followed by reactions to introduce the fluorine atom or carboxylic acid group.
  3. Starting from Fluorinated Anilines: A fluorinated aniline, such as 4-amino-3-fluorotoluene, could undergo oxidation of the methyl group to a carboxylic acid.

Manufacturers often optimize these routes for yield, purity, and cost-effectiveness. As a leading manufacturer in China, we employ advanced synthesis techniques to ensure the high purity (≥98.0%) of our 4-Amino-3-fluorobenzoic acid, making it readily available for purchase by researchers and industries.

Sourcing for Your Synthesis Needs

When you are looking to buy 4-amino-3-fluorobenzoic acid, consider working with a reliable supplier that can provide detailed specifications and consistent quality. Our commitment as a manufacturer is to deliver this vital intermediate with the purity and reliability your projects demand. We offer competitive price points and flexible purchasing options, ensuring you have access to the building blocks necessary for your success in organic synthesis.

In conclusion, understanding the chemical properties and synthesis of 4-Amino-3-fluorobenzoic acid empowers chemists to utilize it effectively. Its versatile reactivity makes it an indispensable intermediate, and sourcing from a trusted manufacturer guarantees the quality needed for demanding applications.