Understanding the chemical nuances of key intermediates is fundamental for anyone involved in advanced organic synthesis, pharmaceuticals, or agrochemicals. 4-Fluoro-2-hydroxybenzoic Acid (CAS 345-29-9), also known as 4-Fluorosalicylic Acid, is one such compound whose structural features lend themselves to a diverse range of synthetic applications. NINGBO INNO PHARMCHEM CO.,LTD., a dedicated manufacturer and supplier, provides this compound with detailed technical specifications to support your scientific endeavors.

Chemical Profile and Properties

4-Fluoro-2-hydroxybenzoic Acid is characterized by its aromatic ring substituted with a carboxylic acid group (-COOH), a hydroxyl group (-OH), and a fluorine atom (-F). Its molecular formula is C7H5FO3, and its molar mass is approximately 156.11 g/mol. Key physical properties often include:

  • Appearance: Typically described as a white to orange crystalline powder.
  • Melting Point: Reports suggest a melting point around 170 °C (with decomposition), indicating a relatively stable solid at room temperature.
  • Solubility: It is known to be soluble in methanol and potentially other polar organic solvents, which is crucial for its use in synthesis reactions.

The fluorine atom, being highly electronegative, influences the electronic distribution of the aromatic ring and can affect the acidity of the carboxylic acid group and the reactivity of the hydroxyl group. This makes it a valuable tool for fine-tuning molecular properties in synthetic chemistry.

Synthetic Pathways and Applications

While detailed proprietary synthesis routes vary among manufacturers, common strategies for producing fluorinated aromatic compounds like 4-Fluoro-2-hydroxybenzoic Acid often involve:

  • Electrophilic Fluorination: Introducing fluorine into a pre-existing aromatic ring structure using specialized fluorinating agents.
  • Nucleophilic Aromatic Substitution: Replacing a leaving group (like a halide or nitro group) with a fluoride source on an activated aromatic ring.
  • Diazotization and Fluorination (Balz-Schiemann Reaction): Converting an amine group to a diazonium salt, followed by treatment with a fluoride source.

The primary utility of 4-Fluoro-2-hydroxybenzoic Acid lies in its role as an intermediate. It serves as a critical building block for:

  • Pharmaceuticals: Synthesis of Active Pharmaceutical Ingredients (APIs) where the fluorine atom provides desirable pharmacokinetic properties.
  • Agrochemicals: Development of herbicides, pesticides, and fungicides with enhanced efficacy and stability.
  • Material Science: Creating specialized polymers or functional materials.

For researchers and industrial chemists, sourcing this compound from a reliable manufacturer is paramount. NINGBO INNO PHARMCHEM CO.,LTD. ensures that the 4-Fluoro-2-hydroxybenzoic Acid we supply adheres to strict purity standards, making it suitable for demanding synthetic applications. We offer competitive pricing and reliable delivery to support your research and production needs.

If you are looking to purchase 4-Fluoro-2-hydroxybenzoic acid or require detailed specifications, please contact our sales team. As a dedicated supplier and manufacturer based in China, we are committed to providing the high-quality chemical intermediates that drive scientific and industrial progress.