For chemists and procurement professionals in the fine chemical and pharmaceutical industries, understanding the fundamental properties and synthesis pathways of key intermediates is crucial. 5-Fluoro-2-oxindole (CAS 56341-41-4) is one such compound, valued for its utility in sophisticated organic synthesis, particularly in pharmaceutical research.

Understanding 5-Fluoro-2-oxindole: Properties and Appearance

5-Fluoro-2-oxindole typically presents as an off-white to pale yellow crystalline powder. Its molecular formula is C8H6FNO, with a molecular weight of 151.14 g/mol. Key physicochemical properties include a melting point generally reported between 143-147°C (though some sources indicate decomposition around 215–220°C, highlighting the importance of precise specifications). Solubility in common organic solvents like DMSO and methanol is noted, while its solubility in water is limited. From a safety perspective, it is often classified as an irritant, requiring appropriate handling procedures.

Synthesis Pathways Explained

The preparation of 5-Fluoro-2-oxindole often begins with readily available starting materials. A common route involves using 4-fluoroaniline. This is typically reacted with chloral hydrate and hydroxylamine hydrochloride to form 4-fluoroisonitrosoacetanilide. Subsequent cyclization, often facilitated by concentrated sulfuric acid, yields 5-fluoroisatin. The final step commonly involves a Wolff-Kishner-Huang minlon reduction to produce 5-Fluoro-2-oxindole. The overall yield for this process can be around 66%, underscoring the importance of optimized reaction conditions and purification.

Sourcing High-Quality 5-Fluoro-2-oxindole

As a leading manufacturer and supplier of pharmaceutical intermediates in China, we specialize in providing 5-Fluoro-2-oxindole that meets stringent quality requirements. Our products are characterized by:

  • Guaranteed Purity: We ensure our 5-Fluoro-2-oxindole meets a minimum purity of 98.0% (HPLC), vital for your synthesis needs.
  • Detailed Specifications: We provide comprehensive documentation, including product specifications and safety data sheets, to support your procurement and research.
  • Reliable Manufacturing: Our advanced facilities and quality control systems ensure a consistent and dependable supply for both R&D and commercial applications.
  • Competitive Pricing: We offer competitive pricing for bulk purchases, making it cost-effective to buy this essential intermediate from us.

For researchers and companies requiring a reliable source of 5-Fluoro-2-oxindole for pharmaceutical, agrochemical, or material science applications, understanding its properties and synthesis is key. We are committed to being your trusted supplier, offering high-quality products and exceptional service. Contact us to learn more about purchasing this versatile chemical intermediate.