Understanding the chemical properties and synthesis routes of key intermediates is fundamental for chemists engaged in pharmaceutical development. 6,7-Dimethoxy-3,4-dihydroquinazolin-4-one (CAS: 13794-72-4) is one such compound, notable for its role as a precursor in the synthesis of targeted therapies.

Chemically, 6,7-Dimethoxy-3,4-dihydroquinazolin-4-one possesses a quinazolinone core substituted with two methoxy groups at positions 6 and 7. Its molecular formula is C10H10N2O3, and it has a molecular weight of approximately 206.2 g/mol. The compound typically appears as a white to near-white solid powder, with a high melting point often above 298°C, indicating its stability as a solid.

The synthesis of 6,7-Dimethoxy-3,4-dihydroquinazolin-4-one typically involves cyclization reactions starting from appropriate substituted anthranilic acid derivatives. For instance, ethyl 2-amino-4,5-dimethoxybenzoate can be reacted with formamide or formamidine hydrochloride under suitable conditions to yield the desired quinazolinone structure. These reactions are often optimized for yield and purity, ensuring that the resulting product meets the stringent requirements for pharmaceutical intermediates.

The compound's significance is largely tied to its utility in the synthesis of Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used in cancer treatment. As a key building block, its availability from reliable manufacturers is crucial for the continuous production of this life-saving medication. Researchers often buy this compound for its efficient incorporation into more complex molecular architectures.

Furthermore, insights into its chemical properties also reveal its potential as a Gefitinib impurity. This means that accurate analytical methods are necessary to identify and quantify its presence, and high-purity samples are required as reference standards. Any scientist or procurement manager looking to buy this chemical should verify its purity via HPLC and consult the CAS number (13794-72-4) for precise identification.

For those seeking to source 6,7-Dimethoxy-3,4-dihydroquinazolin-4-one, partnering with manufacturers who provide detailed technical data and certificates of analysis ensures that the compound's chemical integrity is maintained, thereby facilitating successful research and development outcomes.