For chemists and material scientists, understanding the fundamental properties and synthesis routes of key chemical intermediates is essential for innovation. 6-Bromo-1H-pyrazolo[4,3-b]pyridine (CAS: 1150617-54-1) is a significant heterocyclic compound that warrants a closer look due to its utility in advanced chemical synthesis.

Chemical Profile of 6-Bromo-1H-pyrazolo[4,3-b]pyridine

This compound, with the molecular formula C6H4BrN3 and a molecular weight of 198.02 g/mol, is characterized by its heterocyclic structure, combining pyrazole and pyridine rings. It typically appears as a light yellow to yellow solid. Key physical properties often cited include a boiling point of approximately 329.0±22.0 °C at 760 mmHg and a density of around 1.895 g/cm³. Its pKa value is predicted to be around 9.72±0.40. These physical and chemical characteristics are vital for chemists when designing reaction conditions and understanding the compound's behavior in various solvents and environments.

Synthesis Pathways and Procurement

While specific synthesis details can be complex, general methods for preparing 6-Bromo-1H-pyrazolo[4,3-b]pyridine often involve cyclization reactions with appropriate precursors. For example, one route might involve reacting a substituted pyridine derivative with a hydrazine source. The yield and purity depend heavily on the specific reaction conditions, reagents, and purification techniques employed. For researchers and manufacturers looking to buy this compound, it is crucial to source it from a reliable supplier that meticulously controls the synthesis process.

As a dedicated manufacturer and supplier of fine chemicals, we ensure that our 6-Bromo-1H-pyrazolo[4,3-b]pyridine, with a guaranteed purity of 97% min, is produced under strict quality control measures. This attention to detail is critical for its intended applications, primarily as a pharmaceutical intermediate. We provide comprehensive documentation, including COAs, to verify the quality of the material you purchase.

Applications and Research Potential

The primary application of 6-Bromo-1H-pyrazolo[4,3-b]pyridine is as a building block in the synthesis of pharmaceuticals and other fine chemicals. Its structure is amenable to various functionalization strategies, making it a versatile tool for medicinal chemists developing new drug candidates. The bromine atom's reactivity in cross-coupling reactions allows for the facile introduction of diverse side chains, which can significantly influence biological activity. Consequently, this compound is a valuable asset for any research program focused on novel molecular design.

For those needing to purchase this intermediate, working with a trusted manufacturer offers peace of mind regarding quality and consistency. We invite you to inquire about our product and discuss how we can support your research needs with reliable supply and expert knowledge.