Understanding the fundamental chemical properties of an intermediate is crucial for its effective application in synthesis. 3-Bromo-2-fluorotoluene, identified by CAS 59907-12-9, is a halogenated aromatic compound widely utilized in organic synthesis. Its specific arrangement of bromine, fluorine, and methyl groups on a benzene ring confers unique reactivity, making it a valuable building block for both pharmaceutical and agrochemical industries. As a leading supplier, we provide insights into its key characteristics and how they translate into practical synthesis applications.

Key Chemical Properties of 3-Bromo-2-fluorotoluene

The physical and chemical properties of 3-Bromo-2-fluorotoluene dictate its behavior in chemical reactions and handling. Key properties include:

  • Appearance: Typically appears as a light yellow transparent liquid.
  • Molecular Formula: C7H6BrF
  • Molecular Weight: 189.03 g/mol
  • Boiling Point: Approximately 186 °C. This moderate boiling point allows for efficient distillation and purification processes.
  • Density: Around 1.52 g/cm³. This density is important for volume-to-mass calculations and reaction stoichiometry.
  • Flash Point: Around 76 °C. This indicates its flammability and requires appropriate handling precautions.
  • Refractive Index: Typically around 1.533. This is a useful parameter for identification and quality control.
  • Purity: Commonly available at ≥98% purity, ensuring high fidelity in synthesis reactions.

These properties make 3-Bromo-2-fluorotoluene amenable to a range of chemical transformations, including various coupling reactions, nucleophilic substitutions, and electrophilic aromatic substitutions, often facilitated by its strategically positioned halogen atoms.

Synthesis Applications: Where 3-Bromo-2-fluorotoluene Excels

The utility of 3-Bromo-2-fluorotoluene stems from its role as a versatile intermediate. Its applications span several critical sectors:

1. Pharmaceutical Intermediates

In the pharmaceutical industry, this compound is a key starting material or intermediate for synthesizing a diverse array of drug molecules. The presence of fluorine can enhance lipophilicity, metabolic stability, and receptor binding affinity of potential drug candidates. The bromine atom serves as an excellent leaving group or coupling partner in reactions like Suzuki, Sonogashira, or Buchwald-Hartwig couplings, allowing for the introduction of complex molecular fragments. If you are looking to buy high-quality pharmaceutical intermediates, ensuring your source provides reliable 3-Bromo-2-fluorotoluene is a critical first step.

2. Agrochemical Synthesis

The agrochemical sector benefits significantly from the reactivity of 3-Bromo-2-fluorotoluene. It's used in the production of active ingredients for herbicides, insecticides, and fungicides. The fluorine substituent can contribute to the biological activity and persistence of agrochemical compounds, while the bromine facilitates linkage to other functional groups necessary for their pesticidal properties. Sourcing this intermediate from a reputable manufacturer ensures the efficacy and quality of the final agricultural products.

3. Organic Synthesis Building Block

Beyond specific industries, 3-Bromo-2-fluorotoluene is a general-purpose building block for advanced organic synthesis. It enables chemists to construct intricate molecular architectures for materials science, specialty chemicals, and academic research. Its predictable reactivity makes it a cost-effective choice for complex synthetic routes.

Choosing a Reliable Supplier

When you need to purchase 3-Bromo-2-fluorotoluene, selecting a manufacturer that adheres to high standards is paramount. At NINGBO INNO PHARMCHEM CO.,LTD., we pride ourselves on providing intermediates with excellent chemical properties and consistent purity. We understand the demands of our clients and offer competitive pricing for bulk purchases, ensuring you have a dependable source for your synthesis needs. Contact us to learn more about our product specifications and how we can support your manufacturing objectives.