Understanding the chemical properties of intermediates is fundamental for chemists engaged in complex synthesis. 3-Nitrophthalic Anhydride (CAS: 641-70-3) is a versatile organic compound with distinct characteristics that make it highly valuable, particularly in the pharmaceutical industry. Its molecular formula, C8H3NO5, and molecular weight of 193.11 g/mol, hint at its reactivity and suitability for various chemical transformations.

Physically, 3-Nitrophthalic Anhydride is typically described as a white to yellowish crystalline solid, with a melting point around 163-165°C. Its structure features an anhydride ring fused to a benzene ring, with a nitro group substituent. The nitro group is electron-withdrawing, influencing the reactivity of the aromatic ring and the anhydride moiety. This feature is crucial for its applications in reactions like nucleophilic attack and condensation.

The primary and most significant application of 3-Nitrophthalic Anhydride is its role as a key intermediate in the synthesis of Pomalidomide. The condensation reaction between 3-Nitrophthalic Anhydride and 3-Aminopiperidine-2,6-Dione, followed by reduction of the nitro group, forms the backbone of this crucial pharmaceutical agent. The high purity of the anhydride, often specified as ≥98.0% via HPLC, ensures that the subsequent reactions proceed efficiently, yielding the desired product with minimal contaminants.

Beyond its prominent use in Pomalidomide synthesis, 3-Nitrophthalic Anhydride can participate in various other organic reactions. It can be hydrolyzed to form 3-Nitrophthalic Acid, which itself can be a precursor for other derivatives. Its reactivity makes it a useful building block for synthesizing dyes, agrochemicals, and other specialty chemicals. For researchers and manufacturers looking to buy 3-Nitrophthalic Anhydride, understanding these properties allows for broader application exploration.

As a reputable 3-Nitrophthalic Anhydride supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides this compound with stringent quality controls. We ensure that our product meets the high standards required for pharmaceutical manufacturing. Whether you are developing Pomalidomide or exploring novel chemical syntheses, our high-quality intermediate is available for purchase. We offer competitive pricing and reliable delivery from our base in China, supporting your research and commercial production needs.