For chemists and researchers engaged in synthetic organic chemistry, understanding the properties and applications of key intermediates is fundamental to successful project outcomes. 4-Ethynyltetrahydro-2H-pyran (CAS: 1202245-65-5) is one such compound that offers significant versatility due to its unique chemical structure. This article explores its core properties and its valuable role in various synthetic pathways. If you are looking to buy this intermediate, understanding its characteristics is the first step.

Understanding the Chemical Profile of 4-Ethynyltetrahydro-2H-pyran
4-Ethynyltetrahydro-2H-pyran, with the molecular formula C7H10O and a molecular weight of 110.15, presents as a colorless oil. Its key physical properties, as reported, include a boiling point of approximately 138.1±29.0 °C and a density of about 0.93±0.1 g/cm³. For optimal preservation of its integrity and reactivity, it is recommended to store this compound under sealed, dry conditions at a temperature range of 2-8°C. These properties make it amenable to standard laboratory handling and storage protocols, ensuring its usability for synthesis.

Synthetic Utility and Applications
The primary utility of 4-Ethynyltetrahydro-2H-pyran lies in its role as a versatile building block in organic synthesis. The terminal alkyne (ethynyl) group is a highly reactive functional group, capable of participating in a wide array of transformations. These include, but are not limited to, copper-catalyzed azide-alkyne cycloaddition (click chemistry), Sonogashira coupling, and various addition reactions. Its specific application in the preparation of aminopyrazine derivatives for PI3k-γ inhibitor development underscores its importance in medicinal chemistry. Researchers looking to synthesize complex heterocyclic compounds or novel drug candidates often find this intermediate to be an invaluable starting material. When you consider its applications, purchasing a high-purity grade from a reliable supplier is crucial.

Procurement and Partnership Considerations
As a manufacturer and supplier, we recognize the critical need for consistent quality and reliable access to intermediates like 4-Ethynyltetrahydro-2H-pyran. We ensure that our product meets the high purity standards (≥97%) required by advanced synthetic chemists. Whether you are a researcher in academia or a process chemist in the pharmaceutical industry, partnering with us means gaining access to a dependable source for your material needs. If you are interested in purchasing this chemical or exploring custom synthesis options, we encourage you to reach out for a quote and sample to assess its suitability for your specific research or production goals.