(E)-4-(Dimethylamino)but-2-enoic acid, also known by its hydrochloride salt form (CAS 98548-81-3), is a fascinating molecule with significant utility in advanced organic synthesis. As a fine chemical intermediate, it possesses a unique combination of functional groups – a carboxylic acid, a tertiary amine, and an alpha,beta-unsaturated system – which opens up a wide array of synthetic possibilities.

The compound typically presents as a white to off-white solid. Its chemical structure allows it to participate in various reactions, including nucleophilic additions, esterifications, and amide formations. The presence of the dimethylamino group imparts basicity and nucleophilicity, while the carboxylic acid group provides acidity and reactivity for derivatization. The unsaturated bond is susceptible to Michael additions and cycloaddition reactions.

In the realm of pharmaceutical research, this intermediate is highly valued for its role in constructing complex heterocyclic ring systems. For instance, it is a precursor in the synthesis of tricyclic nitrogen heterocyclic compounds, which are often explored for their therapeutic potential, particularly as anti-cancer agents. Researchers looking to buy this compound for such applications will seek high purity grades, often above 98%, to ensure predictable and efficient reaction outcomes. Manufacturers in China are a primary source for such materials, offering both quality and competitive pricing.

When considering the purchase of (E)-4-(Dimethylamino)but-2-enoic acid or its hydrochloride salt, understanding its properties is key. The melting point range of 157-162 °C for the hydrochloride salt is a standard specification. For R&D purposes or large-scale production, sourcing from a reliable supplier who can provide comprehensive documentation, including Certificates of Analysis, is essential. The versatility of this molecule makes it a valuable asset for chemists working on novel drug discovery and the development of specialized organic materials. Inquire about bulk purchase options to secure a stable supply for your ongoing projects.