In the realm of fine chemicals and pharmaceutical intermediates, understanding the nuanced chemical properties and diverse synthesis applications of a compound is key to its effective utilization. Methyl 2,3-diaminobenzoate (CAS 107582-20-7) is a prime example of such a compound, offering a unique reactivity profile that makes it highly sought after in complex organic synthesis, particularly for pharmaceutical applications.

Unpacking the Chemical Properties

Methyl 2,3-diaminobenzoate, identified by CAS 107582-20-7, possesses the molecular formula C8H10N2O2 and a molecular weight of 166.18. Typically appearing as a slightly yellow powder, its core chemical characteristics stem from the presence of an ester group and two adjacent amine functionalities on an aromatic benzene ring. These amine groups are electron-donating and nucleophilic, enabling reactions such as acylation, alkylation, and participation in cyclization reactions. The ester group can undergo hydrolysis or transesterification under specific conditions. The compound’s melting point is around 68-70°C, indicating it is a solid at room temperature.

Key Synthesis Applications

The versatility of Methyl 2,3-diaminobenzoate makes it an indispensable intermediate in various synthesis pathways. Its most notable application is in the preparation of advanced pharmaceutical intermediates, specifically for cardiovascular drugs like candesartan. For example, it is used in the synthesis of 2-ethoxy-4-carboxylic acid methyl ester-3-hydro-benzimidazole, a crucial step in creating trityl candesartan intermediates. This highlights its importance for drug manufacturers and formulators. If you are a chemist needing to buy Methyl 2,3-diaminobenzoate for these applications, sourcing from a reputable manufacturer that guarantees high purity (≥99.0%) is essential for predictable reaction outcomes.

Reacting with Other Chemical Components

The two amine groups in close proximity on the benzene ring are particularly reactive. They can readily react with electrophiles, such as acid chlorides or anhydrides, to form amides. They also readily participate in condensation reactions with aldehydes or ketones to form imines or heterocyclic ring systems. This characteristic is fundamental to its use in creating complex fused ring structures common in many biologically active molecules. Understanding these reactions allows R&D scientists to efficiently design synthetic routes.

Sourcing for Synthesis Projects

For those looking to buy Methyl 2,3-diaminobenzoate, consider manufacturers and suppliers who provide comprehensive technical data, including detailed specifications and safety information. Companies in China are often leading suppliers, offering competitive pricing and adherence to international quality standards such as GMP. Ensuring a reliable supply chain from a trusted manufacturer is paramount for any ongoing synthesis project, whether for research or commercial production.

Methyl 2,3-diaminobenzoate continues to be a cornerstone intermediate for innovation in the pharmaceutical and fine chemical industries, thanks to its well-defined chemical properties and broad synthesis applicability.