Understanding the fundamental chemical properties and synthesis routes of compounds like Arecoline Hydrobromide (CAS 300-08-3) is essential for effective utilization in research and manufacturing. This alkaloid, derived from the areca nut, presents a unique profile that contributes to its diverse applications.

Arecoline Hydrobromide typically appears as a white to light yellow powder, with a melting point in the range of 171-175 °C. Its solubility in water is reported at 0.1 g/mL, yielding a clear, colorless solution. Chemically, it is represented by the molecular formula C8H13NO2·HBr, with a molecular weight of 236.11. The compound is considered stable for up to two years when stored correctly in a cool, dry, dark location. However, its solutions are not stable and should be prepared fresh daily, highlighting the importance of proper handling procedures.

The synthesis of Arecoline Hydrobromide has been achieved through various methods. Historically, industrial-scale extraction from areca nuts using diethyl ether was common. More modern approaches involve synthetic routes starting from materials like nicotinic acid and iodomethane, or other precursors. The conversion of arecoline into its hydrobromide salt involves dissolving the base in an alcohol solvent and adding hydrobromic acid, followed by crystallization and filtration. For those seeking to buy Arecoline Hydrobromide, understanding these synthesis pathways can inform quality assessment and sourcing decisions from a reputable manufacturer.

Safety considerations are also paramount when handling Arecoline Hydrobromide. It is classified as harmful if swallowed (H302) and requires appropriate protective measures. When heated to decomposition, it can emit toxic fumes of hydrogen bromide and nitrogen oxides. Therefore, strict adherence to safety protocols, including wearing protective gloves, clothing, and eye protection, is imperative. Working with a knowledgeable supplier who provides comprehensive safety data sheets (SDS) is crucial for safe laboratory or industrial practices.

For professionals requiring Arecoline Hydrobromide for their applications, selecting a trusted manufacturer and supplier that offers high-purity material at a competitive price is key. Whether for pharmaceutical intermediates or specialized research, understanding its chemical characteristics and synthesis ensures you are making an informed procurement decision.