For professionals in chemical synthesis and pharmaceutical research, a thorough understanding of the compounds they utilize is crucial. Fmoc-3-L-Ala(2-thienyl)-OH (CAS: 130309-35-2) is a specialized Fmoc-protected amino acid derivative gaining significant traction for its applications in sophisticated organic synthesis, particularly peptide synthesis. As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing detailed insights into this valuable chemical intermediate.

Fmoc-3-L-Ala(2-thienyl)-OH possesses a molecular weight of approximately 393.46 g/mol, with the chemical formula C22H19NO4S. Its structure is characterized by the presence of the Fmoc protecting group on the alpha-amino group and a 2-thienyl group attached to the beta-carbon of the alanine backbone. This unique substitution pattern is key to its utility. The Fmoc group is a standard in Fmoc solid-phase peptide synthesis (SPPS) for its facile cleavage under mild basic conditions, preserving the integrity of the peptide chain. The 2-thienyl moiety, an aromatic heterocycle, contributes to hydrophobicity and can influence the conformational preferences and biological activity of peptides incorporating this residue.

The synthesis of Fmoc-3-L-Ala(2-thienyl)-OH typically involves a multi-step process. A common approach begins with the preparation of the thienylalanine precursor, followed by the introduction of the Fmoc protecting group. This often utilizes reagents like Fmoc-OSu (N-(9-fluorenylmethoxycarbonyloxy)succinimide) in the presence of a mild base. Ensuring high purity during synthesis and subsequent purification steps, such as chromatography, is vital, especially when manufacturing for the demanding pharmaceutical sector. NINGBO INNO PHARMCHEM CO.,LTD. employs rigorous quality control measures to guarantee the purity and consistency of the Fmoc-3-L-Ala(2-thienyl)-OH we supply.

Researchers looking to buy this compound will find its properties particularly useful. Its appearance is typically a white to off-white powder. The compound’s stability and reactivity profile make it an indispensable building block for creating novel peptide libraries, therapeutic peptides, and other complex organic molecules. By sourcing from a reputable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD., you ensure access to high-quality material that supports your research and development goals, whether you are performing laboratory-scale experiments or require bulk quantities for production.

We invite all scientists, procurement managers, and chemists to explore the advantages of using Fmoc-3-L-Ala(2-thienyl)-OH from NINGBO INNO PHARMCHEM CO.,LTD. Our commitment as a manufacturer and supplier is to empower your scientific endeavors with exceptional chemical building blocks.