Methyl 4-methoxyacetoacetate (CAS: 41051-15-4) is a key organic intermediate, recognized for its role in pharmaceutical synthesis, particularly in the production of Dolutegravir. NINGBO INNO PHARMCHEM CO.,LTD. provides this compound, emphasizing its chemical characteristics and manufacturing process.

Chemically, Methyl 4-methoxyacetoacetate is a beta-keto ester with the molecular formula C6H10O4. It presents as a colorless to light yellow liquid, with a density of approximately 1.129 g/mL at 25°C and a boiling point of 89 °C/8.5 mmHg. Its refractive index is around 1.431. These physical properties are indicative of its purity and suitability for fine chemical applications. The compound's structure features a methoxy group and an ester functionality, which contribute to its reactivity in various organic transformations.

The synthesis of Methyl 4-methoxyacetoacetate is typically achieved through the reaction of Methyl 4-chloro-3-oxo-butanoate with methanol in the presence of a base. This process involves a nucleophilic substitution where the chlorine atom is replaced by a methoxy group. NINGBO INNO PHARMCHEM CO.,LTD. employs optimized synthesis protocols to ensure high yields and purity levels, often exceeding 98.5% for this pharmaceutical intermediate. Rigorous quality control measures are in place to verify its composition and remove any potential impurities.

The primary application of Methyl 4-methoxyacetoacetate is as a precursor in the synthesis of Dolutegravir, an important drug for HIV treatment. Its specific structure allows for the efficient construction of the complex molecule required for Dolutegravir's therapeutic action. As a reliable supplier, NINGBO INNO PHARMCHEM CO.,LTD. plays a crucial role in ensuring the availability of this vital intermediate for the global pharmaceutical industry, supporting the production of life-saving medications and contributing to advancements in chemical synthesis.