For professionals deeply involved in chemical research and development, a thorough understanding of key intermediates is foundational. Tert-Butyl Carbamate (CAS 4248-19-5) stands as a significant compound, valued for its distinct chemical properties and its wide-ranging applications, particularly in organic and pharmaceutical synthesis. This article aims to provide insights into its chemical profile, typical synthesis routes, and how to access this important intermediate from reliable manufacturers.

Tert-Butyl Carbamate, represented by the molecular formula C5H11NO2 and the CAS number 4248-19-5, is a carbamate derivative. Its physical appearance is typically described as white to slightly yellow needles, with a melting point range of 105-108°C, indicating it is a stable solid under ambient conditions. The compound is soluble in common organic solvents like chloroform and methanol, but only slightly soluble in petroleum ether and water. Its pKa value, predicted at around 13.59, gives an indication of its basicity.

The utility of Tert-Butyl Carbamate in synthesis is multifaceted. Its primary role is as a source for the tert-butoxycarbonyl (Boc) protecting group, a staple in peptide synthesis and complex organic molecule construction. The Boc group effectively shields amine functionalities during reactions and can be removed under mild acidic conditions. This makes Tert-Butyl Carbamate an indispensable reagent for synthetic chemists aiming for precision and efficiency in multi-step syntheses. Its application in palladium-catalyzed cross-coupling reactions to form N-Boc protected anilines is a testament to its versatility.

Furthermore, Tert-Butyl Carbamate serves as a precursor in the synthesis of heterocyclic compounds, such as tetrasubstituted pyrroles. These structures are often found in biologically active molecules, making the intermediate valuable for pharmaceutical and medicinal chemistry research. The ability to efficiently synthesize complex ring systems using readily available building blocks like Tert-Butyl Carbamate streamlines the discovery and development process for new drugs and materials.

For R&D scientists and procurement managers looking to buy Tert-Butyl Carbamate, understanding its synthesis pathways can be beneficial. Common raw materials used in its preparation include tert-butanol, di-tert-butyl dicarbonate, and ammonia or related nitrogen sources, often involving specific catalysts and reaction conditions. Manufacturers typically optimize these processes for yield, purity, and cost-effectiveness, often achieving purities of 98% or higher.

When sourcing Tert-Butyl Carbamate, especially in bulk quantities, partnering with reputable chemical manufacturers is essential. Companies in China are well-established producers of fine chemical intermediates like this one. It is important to find suppliers that can guarantee consistent quality, provide detailed technical data, and offer competitive pricing. Requesting quotes for CAS 4248-19-5 from several verified manufacturers will allow for informed purchasing decisions, ensuring the best value and reliability for your research or production needs.

In conclusion, Tert-Butyl Carbamate (CAS 4248-19-5) is a chemically significant intermediate with robust applications in protecting group chemistry and heterocyclic synthesis. Its properties as white to yellow needles and high purity make it a preferred choice for demanding chemical applications. By engaging with knowledgeable manufacturers and suppliers, researchers and procurement professionals can effectively secure this vital compound, contributing to the advancement of chemical science and industry.