For chemists and researchers engaged in organic synthesis, understanding the specific chemical properties and reactive potential of a compound is paramount. 4-Fluorobenzonitrile (CAS 1194-02-1) is a molecule that offers a fascinating blend of reactivity and stability, making it a highly valuable intermediate in a multitude of synthesis pathways. Its structure, featuring an electron-withdrawing nitrile group and a fluorine atom on an aromatic ring, dictates its behavior in chemical reactions, enabling sophisticated molecular construction.

Key Chemical Properties of 4-Fluorobenzonitrile

4-Fluorobenzonitrile is characterized by its relatively high purity, often specified at 99% or greater when sourced from reputable manufacturers. Physically, it typically presents as a white crystalline solid with a melting point around 34°C. Its boiling point is approximately 188°C, indicating moderate volatility. The presence of the fluorine atom on the para position of the benzene ring significantly influences the electron distribution within the molecule. Fluorine is highly electronegative, leading to a polarization of the C-F bond and influencing the reactivity of the aromatic ring towards electrophilic and nucleophilic substitution reactions. The nitrile group (C≡N) is also a strong electron-withdrawing group, further activating the ring in specific ways and offering a site for various transformations, such as hydrolysis to carboxylic acids or reduction to amines.

Synthesis Applications and Opportunities

The versatility of 4-Fluorobenzonitrile as a synthetic intermediate is evident in its wide range of applications. Researchers often leverage its structure to introduce the 4-fluorophenyl moiety into larger, more complex molecules. This is particularly relevant in:

  • Pharmaceutical Synthesis: It serves as a precursor for active pharmaceutical ingredients (APIs) where the fluorophenyl group contributes to drug efficacy, binding affinity, and metabolic stability. When you look to buy 4-Fluorobenzonitrile for your drug discovery pipeline, consider its role in synthesizing anti-inflammatory agents or neurological drugs.
  • Agrochemical Development: The compound is used in the creation of novel pesticides and herbicides, where fluorination can enhance biological activity and persistence. Farmers and agrochemical companies sourcing this intermediate benefit from its ability to improve crop protection solutions.
  • Material Science: In the development of specialty materials, including polymers and organic electronic components, the unique electronic and physical properties imparted by the fluorobenzonitrile structure are highly valued.

For procurement managers and scientists, securing a reliable supply of 4-Fluorobenzonitrile from a qualified manufacturer in China is essential. When you purchase this chemical, paying attention to detailed product specifications, safety data sheets (SDS), and Certificates of Analysis (CoA) ensures you are obtaining a product that meets your rigorous research and development needs. The price of 4-Fluorobenzonitrile can vary based on purity and quantity, making direct inquiries to manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. a smart approach to procurement.

In essence, 4-Fluorobenzonitrile is more than just a chemical compound; it's a gateway to creating advanced materials and life-saving medicines. Understanding its chemical properties empowers researchers to unlock its full synthetic potential.