In the highly regulated pharmaceutical industry, the quality of every component, especially chemical intermediates, is non-negotiable. The intermediate 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide serves as a prime example of a compound where precise specifications directly translate to product integrity and efficacy. Its primary application as a Sorafenib intermediate means that any compromise in its purity or consistency could affect the final drug's therapeutic performance and safety profile.

Understanding the key specifications for 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide is crucial for chemists and procurement specialists. A high purity level, typically stated as ≥98.0% as determined by HPLC, is fundamental. This high purity ensures that the subsequent reactions in the Sorafenib synthesis pathway proceed with minimal side reactions, leading to a cleaner final product. Furthermore, stringent control over impurities, with single impurities often limited to ≤0.5% and total impurities to ≤1.0%, is vital for meeting regulatory standards.

Beyond chemical purity, physical and chemical properties also play a significant role. The appearance of the intermediate, described as a white powder, is a visual indicator of quality. Additionally, parameters such as low water content (≤0.2%) and a minimal residue on ignition (0.05%) are critical. High water content can interfere with certain chemical reactions or lead to degradation, while a high residue on ignition might indicate the presence of inorganic contaminants. These factors are meticulously monitored by API intermediate manufacturers to ensure that their products meet the demanding requirements of pharmaceutical production.

For those involved in chemical synthesis and drug development, sourcing intermediates that adhere to these strict specifications is paramount. Choosing a supplier that provides detailed Certificates of Analysis (CoA) for compounds like 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide is essential for quality assurance. This transparency allows researchers and manufacturers to confidently integrate the intermediate into their processes, knowing they are working with a material that meets the highest standards, thereby supporting the overall goal of delivering safe and effective pharmaceutical products to patients.