In the intricate world of organic synthesis, certain molecules stand out for their versatility and ability to serve as foundational building blocks for complex structures. 2-Bromo-5-cyanopyridine, identified by CAS number 139585-70-9, is one such compound. As a premier supplier and manufacturer, we offer this essential intermediate, understanding its critical role in enabling chemists to create novel compounds with diverse applications, from pharmaceuticals to advanced materials.

Understanding the Reactivity of 2-Bromo-5-cyanopyridine

The inherent reactivity of 2-Bromo-5-cyanopyridine stems from its unique structural features: a pyridine ring substituted with both a bromine atom and a cyano group. This combination provides chemists with multiple avenues for functionalization:

  • Nucleophilic Aromatic Substitution (SNAr): The bromine atom at the 2-position of the pyridine ring is an excellent leaving group. It can be readily displaced by various nucleophiles, such as amines, alkoxides, and thiols. This SNAr reactivity is crucial for introducing diverse heteroatom functionalities into the pyridine core, a common strategy in drug discovery.
  • Cross-Coupling Reactions: The aryl bromide moiety is a prime substrate for a multitude of palladium-catalyzed cross-coupling reactions. Suzuki-Miyaura couplings with boronic acids, Sonogashira couplings with alkynes, and Buchwald-Hartwig aminations are all highly effective with 2-Bromo-5-cyanopyridine. These reactions allow for the formation of new carbon-carbon and carbon-nitrogen bonds, enabling the construction of complex conjugated systems and biologically active molecules. If you are looking to buy these building blocks, consider our high-purity offering.
  • Transformations of the Cyano Group: The cyano group itself is a versatile functional handle. It can be reduced to a primary amine (-CH₂NH₂), hydrolyzed to a carboxylic acid (-COOH) or amide (-CONH₂), or participate in cycloaddition reactions. This versatility further expands the synthetic possibilities when using 2-Bromo-5-cyanopyridine as a starting material.

Why Choose Us as Your Supplier?

As a leading manufacturer in China, we are committed to providing high-quality 2-Bromo-5-cyanopyridine with exceptional purity (99% min). We understand that the success of complex synthetic routes depends on the reliability and consistency of the starting materials. Our efficient production processes and stringent quality control measures ensure that you receive a product that meets your exact specifications, allowing you to focus on achieving breakthrough results in your research. We offer competitive pricing and a stable supply chain, making us an ideal partner for your chemical synthesis needs. For a reliable source to buy this intermediate, look no further.

Applications and Future Directions

The rich chemistry of 2-Bromo-5-cyanopyridine makes it indispensable in the synthesis of pharmaceutical intermediates, agrochemicals, and advanced materials like fluorescent probes and porous frameworks. Its ability to undergo a wide array of transformations means it can be tailored to specific applications, driving innovation across multiple industries. As researchers continue to explore novel catalytic systems and reaction methodologies, the utility of this key intermediate is only set to grow.