The Chemical Reactivity of 3-Iodoaniline (CAS 626-01-7) Explained
Understanding the chemical reactivity of intermediates is fundamental for any chemist aiming to design efficient synthesis routes. 3-Iodoaniline, bearing the CAS number 626-01-7, is a prime example of a molecule whose reactivity makes it indispensable in modern organic chemistry. NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer committed to providing high-quality 3-Iodoaniline to facilitate your research and production.
The reactivity of 3-Iodoaniline stems from its bifunctional nature: it possesses both an amine group (-NH2) and an iodine atom (-I) attached to a benzene ring. This combination allows for a broad spectrum of chemical transformations.
The amine group is nucleophilic and can readily undergo reactions such as:
The iodine atom, being a good leaving group, is particularly valuable for carbon-carbon bond formation, especially through transition-metal-catalyzed cross-coupling reactions. These include:
These powerful reactions allow chemists to precisely assemble complex molecular structures, making 3-Iodoaniline a critical component in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. For anyone looking to buy 3-Iodoaniline, NINGBO INNO PHARMCHEM CO.,LTD. offers a high-purity product that ensures reliable reactivity for your demanding applications. We are proud to be a trusted supplier in China, providing the chemical building blocks necessary for innovation. Inquire today to learn more about the applications and availability of our 3-Iodoaniline.
The reactivity of 3-Iodoaniline stems from its bifunctional nature: it possesses both an amine group (-NH2) and an iodine atom (-I) attached to a benzene ring. This combination allows for a broad spectrum of chemical transformations.
The amine group is nucleophilic and can readily undergo reactions such as:
- Acylation: Reaction with acid chlorides or anhydrides to form amides.
- Alkylation: Reaction with alkyl halides to form secondary or tertiary amines.
- Diazotization: Reaction with nitrous acid to form a diazonium salt, which can then undergo various Sandmeyer-type reactions or azo coupling.
The iodine atom, being a good leaving group, is particularly valuable for carbon-carbon bond formation, especially through transition-metal-catalyzed cross-coupling reactions. These include:
- Suzuki-Miyaura Coupling: Reaction with boronic acids or esters to form biaryl compounds or substituted aromatics.
- Heck Reaction: Reaction with alkenes to introduce vinyl groups.
- Sonogashira Coupling: Reaction with terminal alkynes to form internal alkynes.
- Buchwald-Hartwig Amination: Reaction with amines to form C-N bonds.
These powerful reactions allow chemists to precisely assemble complex molecular structures, making 3-Iodoaniline a critical component in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. For anyone looking to buy 3-Iodoaniline, NINGBO INNO PHARMCHEM CO.,LTD. offers a high-purity product that ensures reliable reactivity for your demanding applications. We are proud to be a trusted supplier in China, providing the chemical building blocks necessary for innovation. Inquire today to learn more about the applications and availability of our 3-Iodoaniline.
Perspectives & Insights
Chem Catalyst Pro
“The amine group is nucleophilic and can readily undergo reactions such as:Acylation: Reaction with acid chlorides or anhydrides to form amides.”
Agile Thinker 7
“Diazotization: Reaction with nitrous acid to form a diazonium salt, which can then undergo various Sandmeyer-type reactions or azo coupling.”
Logic Spark 24
“The iodine atom, being a good leaving group, is particularly valuable for carbon-carbon bond formation, especially through transition-metal-catalyzed cross-coupling reactions.”