In the intricate landscape of modern organic synthesis, certain compounds emerge as indispensable tools for chemists. 1-Adamantaneacetic Acid (CAS 4942-47-6) is one such molecule, celebrated for its distinctive adamantane framework and its role as a potent acylating agent. As a chemical supplier specializing in high-quality intermediates, we understand the value this compound brings to research and development across various industries, particularly in pharmaceuticals and fine chemicals.

Understanding the Chemical Structure and Properties

1-Adamantaneacetic Acid is characterized by its robust, cage-like adamantane structure, which imparts significant steric bulk and lipophilicity to molecules it's incorporated into. Chemically, it is a carboxylic acid with the formula C12H18O2. Its typical appearance is an off-white crystal, and it possesses a melting point in the range of 116-119°C. These physical properties make it relatively stable and easy to handle in a laboratory setting. The presence of the carboxylic acid group makes it an excellent precursor for esterification, amidation, and other reactions that utilize acylating agents.

As an acylating agent, 1-Adamantaneacetic Acid facilitates the introduction of the 1-adamantylacetyl group into target molecules. This process is vital in modifying the properties of existing compounds, often to enhance their biological activity, stability, or pharmacokinetic profiles. This is precisely why it finds significant application in the pharmaceutical sector, where researchers are constantly seeking to optimize drug candidates.

Applications in Pharmaceutical and Chemical Research

The primary application of 1-Adamantaneacetic Acid lies in its use as an acylating agent in the synthesis of novel organic compounds. In pharmaceutical research, it has been instrumental in synthesizing analogues of biologically active molecules, such as bradykinin. By modifying the N-terminal part of these analogues with the 1-adamantylacetyl group, researchers can explore how these structural changes affect pharmacological characteristics, leading to the development of potential new therapeutics.

Furthermore, 1-Adamantaneacetic Acid has been identified as an inhibitor of specific enzymes, including chorismate mutase-prephenate dehydrogenase. This enzyme inhibition property opens avenues for its use in biochemical studies, metabolic pathway research, and potentially in the development of enzyme-targeted therapies. For scientists looking to purchase 1-adamantaneacetic acid for such specialized applications, sourcing from a reputable manufacturer like us ensures the required purity and quality.

Why Choose Us for Your 1-Adamantaneacetic Acid Needs?

As a dedicated chemical supplier, we understand the critical importance of reliable raw materials. When you buy 1-Adamantaneacetic Acid from us, you are assured of a product that meets high purity standards (typically 98.5% min). We serve as a key manufacturer and supplier, offering competitive pricing and consistent availability for this vital chemical intermediate. Our goal is to support your research and development efforts by providing seamless access to essential building blocks.

We encourage procurement managers and research scientists to consider us for their needs when looking to purchase 1-adamantaneacetic acid. Our commitment to quality, coupled with our competitive pricing for bulk orders, makes us an ideal partner for your chemical sourcing requirements. Contact us today to request a quote and discuss how our 1-adamantaneacetic acid can empower your next synthesis project.