In the realm of organic chemistry and pharmaceutical development, certain molecules serve as indispensable building blocks, enabling the creation of complex and vital compounds. 2-Amino-4-chloropyrimidine (CAS 3993-78-0) is one such versatile intermediate. Its unique structural features, combining an amino group and a chlorine atom on a pyrimidine ring, make it a highly sought-after reagent for a variety of synthetic transformations. Understanding its properties and applications is crucial for researchers and procurement specialists looking to buy this essential chemical.

Chemical Profile and Properties

2-Amino-4-chloropyrimidine is characterized by its molecular formula C4H4ClN3 and a molecular weight of 129.55. Typically appearing as an off-white to light brown powder, it possesses a defined melting point range of 155-160°C (with decomposition). Its chemical reactivity stems from the nucleophilic amino group and the electrophilic carbon atom bearing the chlorine substituent, which can be readily displaced in various substitution reactions. These properties make it a valuable synthon in heterocyclic chemistry.

Key Applications in Synthesis

One of the most significant applications of 2-Amino-4-chloropyrimidine is its role as a key intermediate in the synthesis of Rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection. The precise incorporation of this pyrimidine derivative into the Rilpivirine molecular structure highlights its importance in pharmaceutical manufacturing. Beyond Rilpivirine, this compound is also employed in the development of other novel pharmaceuticals and fine chemicals. Researchers often seek out this compound when exploring new synthetic routes for drug discovery and material science.

Sourcing and Availability

For those looking to purchase 2-Amino-4-chloropyrimidine, finding a reliable supplier is essential. As a manufacturer and supplier, we provide high-purity 2-Amino-4-chloropyrimidine, ensuring it meets the demanding specifications of advanced synthesis. Whether for R&D purposes or commercial production, understanding the availability and pricing from reputable sources like ours is a key step for any chemist or procurement manager. By sourcing this fundamental building block, you empower your research and manufacturing capabilities.