The synthesis of peptides, especially those destined for pharmaceutical or biotechnological applications, relies heavily on precisely engineered chemical building blocks. Among these, Fmoc-HomoArg(Pbf)-OH (CAS 401915-53-5) holds significant chemical importance. This protected amino acid derivative is a staple for researchers employing the Fmoc strategy in Solid-Phase Peptide Synthesis (SPPS).

Chemically, Fmoc-HomoArg(Pbf)-OH is a derivative of homoarginine, an amino acid analogous to arginine but with an additional methylene group in its side chain. This elongation can impart unique properties to the resulting peptide. The molecule features two key protective groups: the N-alpha-Fmoc (9-fluorenylmethyloxycarbonyl) group, which is base-labile and removed by agents like piperidine, and the N-omega-Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group, which shields the highly reactive guanidino function of homoarginine. The Pbf group is designed to be stable during the Fmoc deprotection step but readily cleaved under acidic conditions, typically by trifluoroacetic acid (TFA), during the final cleavage of the peptide from the resin.

From a manufacturer's perspective, producing Fmoc-HomoArg(Pbf)-OH with high purity is paramount. Our process ensures a minimum purity of 95% by HPLC, guaranteeing that the reagent will perform reliably in complex peptide synthesis protocols. The typical white to slight yellow to beige powder appearance is a visual confirmation of product quality. For those looking to buy this essential chemical, understanding these specifications is critical for project success.

The Pbf group's specific role is to prevent unwanted side reactions involving the guanidino group during the iterative cycles of peptide chain elongation. Its bulkiness and chemical nature protect against premature reactions, ensuring that only the intended amino acid coupling occurs. This makes Fmoc-HomoArg(Pbf)-OH an indispensable reagent when constructing peptide sequences that require the incorporation of homoarginine for specific biological functions or structural integrity.

As a supplier based in China, we aim to provide researchers and developers with consistent access to this high-quality chemical. The demand for such specialized amino acid derivatives underscores the growth in peptide-based therapeutics and research tools. By offering competitive pricing and reliable supply, we support the advancement of scientific discovery.

In essence, the chemical structure and the strategic use of protective groups in Fmoc-HomoArg(Pbf)-OH make it a vital component in modern peptide synthesis. Its availability from reputable manufacturers ensures that researchers can confidently buy and utilize this compound for their most demanding projects.