For chemists, researchers, and procurement professionals, understanding the precise specifications of chemical compounds is fundamental to successful research, development, and manufacturing. This article focuses on 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile (CAS 138564-59-7), a significant organic intermediate, and aims to clarify its key technical attributes.

Core Identity and Structure

The chemical identity of 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile is clearly defined by its CAS number, 138564-59-7, and its molecular formula, C12H9N3O2S. This formula indicates a molecular weight of approximately 259.28 g/mol. The compound's structure features a central thiophene ring substituted with a methyl group, a nitrile group, and an amino linkage to a 2-nitrophenyl group. This arrangement dictates its chemical behavior and applications.

Key Physical and Chemical Properties

Understanding the physical properties is crucial for handling, storage, and processing:

  • Appearance: Typically described as a solid, with color variations ranging from light yellow to amber or dark green. This visual characteristic can be an initial indicator of purity or batch consistency.
  • Melting Point: The melting point for this compound is consistently reported in the range of 109.0°C to 115.0°C. This parameter is a critical measure of purity, as impurities tend to lower and broaden the melting point range.
  • Solubility: While specific solubility data can vary, it is often noted as slightly soluble in solvents like chloroform and DMSO. This information is vital for preparing solutions for analytical testing or reaction mixtures.
  • Purity: For its use as a pharmaceutical intermediate or impurity standard, high purity is essential. Typical specifications range from 98.0% upwards, often verified by techniques such as TLC (Thin Layer Chromatography) or HPLC (High-Performance Liquid Chromatography).

Applications and Significance

The primary applications for 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile are:

  • Pharmaceutical Intermediate: It serves as a crucial building block in the multi-step synthesis of various pharmaceutical compounds, including Olanzapine.
  • Olanzapine Impurity Standard: It is recognized as Olanzapine Impurity A (or Olanzapine Related Compound A), making it indispensable for quality control and regulatory compliance in Olanzapine manufacturing.
  • Research & Development: Its unique structure and reactivity make it valuable for academic and industrial research in organic chemistry and materials science.

Procurement Considerations: Buying from a Reputable Supplier

When looking to purchase 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile, it is vital to source from manufacturers and suppliers who provide detailed specifications and reliable documentation. We, as a dedicated supplier, offer this compound with guaranteed purity and comprehensive technical data, including Certificates of Analysis (CoA). Understanding the product specifications helps in making informed purchasing decisions and ensuring that the material is suitable for your specific application.

For professionals engaged in chemical procurement and research, a thorough understanding of chemical specifications is a cornerstone of success. 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile exemplifies the importance of precise chemical information for advancing scientific and industrial objectives. Contact us to obtain detailed specifications and a quote for your chemical needs.