For procurement specialists and quality control managers in the chemical and pharmaceutical industries, understanding the precise specifications of intermediates is fundamental. Pyridine-2,5-dicarboxylic Acid (CAS: 100-26-5) is no exception. This article outlines the key chemical and physical properties essential for its effective use and procurement.

The compound, scientifically known as Pyridine-2,5-dicarboxylic acid, has the molecular formula C7H5NO4 and a molecular weight of approximately 167.12 g/mol. Its CAS Registry Number is 100-26-5, and it is also identified by synonyms such as Isocinchomeronic acid or 2,5-Lutidinic acid. These identifiers are crucial for accurate ordering and documentation.

Key Physical and Chemical Properties:

  • Appearance: Typically described as a yellow to green fine crystalline powder. Variations in color can sometimes indicate purity levels or slight differences in crystal form.
  • Melting Point: Reported values often range from 242-247 °C, with decomposition occurring at these temperatures. This high melting point indicates good thermal stability under standard storage conditions.
  • Solubility: It exhibits limited solubility in water (around 1.2 g/L at 25 °C) and is also soluble in alcohol. Understanding its solubility is vital for designing reaction conditions and purification processes.
  • Purity: Reputable manufacturers typically offer Pyridine-2,5-dicarboxylic Acid with a minimum purity of 95%, often specified as 98.0% (GC) or 98.2% (HPLC). High purity is critical for pharmaceutical applications to avoid unwanted side reactions or impurities in the final drug product.
  • Stability: The compound is noted as stable under normal temperatures and pressures. However, some sources mention sensitivity to light and hygroscopicity, suggesting storage in tightly sealed containers, away from light, and potentially under an inert atmosphere, especially for long-term storage.

Handling and Storage Recommendations:

Given its potential light sensitivity and hygroscopic nature, it is advisable to store Pyridine-2,5-dicarboxylic Acid in a cool, dry place, in tightly closed containers, and protected from light. Proper handling procedures, including the use of personal protective equipment (PPE), should be followed as per the Safety Data Sheet (SDS).

For industries requiring this intermediate, securing a reliable supply from manufacturers in China ensures access to competitively priced material that meets stringent quality specifications. Always request a Certificate of Analysis (COA) to confirm the batch-specific properties meet your project requirements. Purchasing Pyridine-2,5-dicarboxylic Acid from trusted suppliers is the first step toward successful synthesis and product development.