For chemists and researchers working with amino acids and peptide synthesis, a thorough understanding of chemical structures and properties is crucial. Fmoc-N-Me-D-Gln(Trt)-OH, a modified amino acid derivative, is one such compound whose characteristics dictate its utility in advanced synthetic applications. As a leading manufacturer and supplier, we aim to provide clarity on these vital aspects.

Fmoc-N-Me-D-Gln(Trt)-OH, with the CAS number 2044710-89-4 and molecular formula C40H36N2O5, represents a sophisticated building block for peptide chemistry. The 'Fmoc' refers to the 9-fluorenylmethyloxycarbonyl protecting group, which is standard in modern Solid Phase Peptide Synthesis (SPPS) due to its mild cleavage conditions. The 'N-Me' indicates an N-methylation on the alpha-amino group, a modification that can impact peptide structure and function. The 'D-Gln' signifies that it is derived from the D-isomer of glutamine, which is often used to introduce specific conformational constraints or resistance to proteolysis in peptides. Finally, '(Trt)' denotes the trityl protecting group attached to the glutamine side chain's amide nitrogen, effectively shielding this reactive moiety during synthesis.

The molecular weight of Fmoc-N-Me-D-Gln(Trt)-OH is approximately 624.72 g/mol. Its appearance is typically described as a white to off-white solid, which is consistent with many protected amino acids used in synthesis. Understanding these basic physical properties is important when you buy Fmoc-N-Me-D-Gln(Trt)-OH. The compound’s solubility in common organic solvents used in SPPS, such as DMF (dimethylformamide) and DCM (dichloromethane), is also a key consideration for efficient reaction kinetics.

The significance of these structural features—N-methylation, D-configuration, and side-chain protection—lies in their ability to enable the synthesis of peptides with specific desired properties. For instance, D-amino acids can increase a peptide's resistance to enzymatic degradation, prolonging its half-life in biological systems. N-methylation can influence peptide conformation and lipophilicity. The trityl group, being acid-labile, can be cleaved during the final deprotection step along with the Fmoc group and other acid-labile side-chain protectors.

For researchers and procurement specialists looking to purchase Fmoc-N-Me-D-Gln(Trt)-OH, sourcing from a reputable Fmoc-N-Me-D-Gln(Trt)-OH manufacturer is paramount. A reliable supplier will provide detailed specifications, including purity analyses (often by HPLC and NMR) and proper handling instructions. The price of Fmoc-N-Me-D-Gln(Trt)-OH will vary based on purity, quantity, and the supplier's capabilities. We, as a leading manufacturer in China, ensure that our product adheres to the highest standards, making it an ideal choice for demanding synthesis projects.

In conclusion, grasping the detailed chemical structure and properties of Fmoc-N-Me-D-Gln(Trt)-OH empowers researchers to make informed decisions in their peptide synthesis strategies. We are committed to providing high-quality chemical intermediates to support your scientific advancements. Contact us to learn more about our product and sourcing options.