2-Thiopheneethanol, known by its CAS number 5402-55-1, is a versatile organic compound that has garnered significant attention in the fields of organic synthesis and pharmaceutical chemistry. This article provides an in-depth exploration of its chemical properties, common synthesis routes, and its broad spectrum of applications.

The molecular formula of 2-Thiopheneethanol is C6H8OS, with a molecular weight of 128.19 g/mol. It is characterized by a thiophene ring attached to an ethanol group. This unique structure imparts specific reactivity that is highly valued in chemical synthesis. The compound is typically described as a colorless to pale yellow liquid, with a density of approximately 1.153 g/mL at 25°C. Its boiling point is around 108-109°C at 13 mmHg, and its refractive index is n20/D 1.551. While slightly soluble in water, it exhibits better solubility in organic solvents like chloroform and ethyl acetate. These physical and chemical characteristics are important for its handling and integration into various reaction systems.

The 2-Thiopheneethanol synthesis often involves sophisticated chemical processes. One common method employs the Heck reaction, starting with 2-bromothiophene. This reaction is facilitated by a palladium catalyst and a solvent like N-Methyl pyrrolidone, and conducted at elevated temperatures. Following the reaction, selective reduction yields the desired product. This approach is favored for industrial production due to its efficiency and the possibility of catalyst recovery. Understanding these synthesis pathways is crucial for ensuring a consistent and high-quality supply of 2-Thiopheneethanol for its various uses.

The applications of 2-Thiopheneethanol are diverse, spanning several key industries. Its primary utility is as a pharmaceutical intermediate. It is a critical precursor in the synthesis of clopidogrel, an essential medication for preventing blood clots. Its role in drug development also extends to other therapeutic agents. Furthermore, the compound's inherent properties make it valuable in broader organic chemistry contexts, where it can be used to prepare specialized molecules, including fluorescent markers for biopolymers.

Beyond pharmaceuticals, 2-Thiopheneethanol shows promise in material science and organic electronics. Its electronic properties could lead to applications in developing advanced materials for devices like OLEDs. The continuous research into its applications highlights its importance as a fundamental building block in chemical innovation. For businesses looking to source this compound, engaging with reputable 2-Thiopheneethanol manufacturers is key to ensuring product quality and reliability. The availability of such intermediates at a competitive 2-Thiopheneethanol price is vital for research and industrial scale-up.

In conclusion, 2-Thiopheneethanol (CAS 5402-55-1) is a compound of significant chemical and commercial value. Its well-defined synthesis routes and broad applications, particularly in the pharmaceutical sector, make it a sought-after chemical. As research progresses, new applications are likely to emerge, further solidifying its position as a vital component in the chemical industry. Companies that buy 2-Thiopheneethanol are investing in the foundational elements of drug development and advanced material creation.