The Chemical Synthesis and Applications of [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic Acid
The field of synthetic chemistry constantly seeks versatile building blocks that can facilitate the creation of complex molecules for pharmaceutical and biotechnological applications. [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (CAS: 166108-71-0) is one such indispensable intermediate, recognized for its role as a hydrophilic, heterobifunctional spacer. As a leading manufacturer and supplier, we provide this high-purity compound to researchers and industries globally, enabling advancements in drug discovery and material science.
The synthesis of [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid involves established organic chemistry principles. Typically, it starts with readily available precursors and progresses through steps that introduce the polyethylene glycol (PEG) chain and the Fmoc-protected amine and carboxylic acid functionalities. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a robust amine protecting group, crucial for selective deprotection during subsequent coupling reactions. The PEG chain contributes hydrophilicity and flexibility, while the terminal carboxylic acid is a reactive handle for amide bond formation. For those looking to buy this intermediate, understanding these synthetic aspects underscores its value.
The applications of [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid are remarkably diverse. In pharmaceutical research, it is a vital intermediate for synthesizing drug candidates targeting various diseases, including those affecting the immune system and metabolic pathways. Its utility as a linker in PROTAC (Proteolysis Targeting Chimera) and ADC (Antibody-Drug Conjugate) technologies further highlights its importance. These advanced therapeutic strategies rely on precise molecular construction, where our compound's dual functionality and favorable physicochemical properties are invaluable.
Beyond its pharmaceutical applications, this PEGylated amino acid derivative can be used in bioconjugation, facilitating the attachment of labels, probes, or other molecules to peptides and proteins. This capability is essential for developing diagnostic tools and advanced research reagents. As a reliable manufacturer and supplier, we ensure that our [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid meets the high purity standards required for these sophisticated applications.
We are committed to supporting scientific innovation by providing access to high-quality chemical synthesis intermediates. If your research or development requires [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, we encourage you to contact us. Explore our competitive pricing and dependable supply chain to fulfill your procurement needs. Partner with us, a trusted manufacturer in China, for your critical chemical intermediate requirements.
Perspectives & Insights
Molecule Vision 7
“The synthesis of [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid involves established organic chemistry principles.”
Alpha Origin 24
“Typically, it starts with readily available precursors and progresses through steps that introduce the polyethylene glycol (PEG) chain and the Fmoc-protected amine and carboxylic acid functionalities.”
Future Analyst X
“The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a robust amine protecting group, crucial for selective deprotection during subsequent coupling reactions.”