The development of potent pharmaceuticals often relies on intricate chemical synthesis routes, where each intermediate plays a pivotal role in achieving the final active pharmaceutical ingredient (API). For Aprepitant, a leading antiemetic drug, the synthesis pathway prominently features 3-Chloromethyl-1,2,4-triazolin-5-one (CAS: 252742-72-6). Understanding the chemical properties and sourcing of this key intermediate is essential for researchers and manufacturers in the pharmaceutical sector.

Aprepitant, a selective neurokinin-1 (NK-1) receptor antagonist, has revolutionized the management of chemotherapy-induced nausea and vomiting. Its complex molecular structure is built through a series of carefully controlled chemical reactions, with 3-Chloromethyl-1,2,4-triazolin-5-one serving as a crucial building block. This triazole derivative provides a core structural element that is further elaborated upon to form the final API. The purity and consistent quality of this intermediate are directly correlated with the efficiency and yield of the Aprepitant synthesis, making it a high-demand chemical.

As a manufacturer and supplier specializing in pharmaceutical intermediates, we offer 3-Chloromethyl-1,2,4-triazolin-5-one with guaranteed high purity (≥98.0%). Our production processes are optimized to ensure minimal side reactions and high yields in subsequent synthetic steps. This focus on quality makes us a preferred supplier for companies engaged in the research, development, and commercial production of Aprepitant and related compounds.

For scientists and procurement specialists aiming to buy this essential intermediate, sourcing from a reliable manufacturer in China, such as ourselves, provides access to critical expertise and competitive pricing. We provide detailed technical data, including chemical properties and safety information, to facilitate your research and manufacturing processes. Whether you require small quantities for laboratory synthesis or large volumes for industrial production, we are equipped to meet your demands.

The efficient synthesis of Aprepitant is a testament to advancements in organic chemistry and the availability of high-quality chemical building blocks. By ensuring a consistent supply of 3-Chloromethyl-1,2,4-triazolin-5-one, we contribute to the broader goal of making effective antiemetic treatments accessible to patients worldwide. We encourage you to contact us for inquiries about purchasing this vital intermediate and to request a quotation for your specific project needs.