Ethyl 3-(pyridin-2-ylamino)propanoate, with its CAS number 103041-38-9, is a highly sought-after intermediate in the pharmaceutical industry, primarily for its role in synthesizing thrombin inhibitors. Understanding its chemical synthesis is crucial for appreciating its value and for ensuring consistent production. NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer in China, plays a vital role in supplying this essential compound, ensuring its availability for research and commercial applications.

The synthesis of Ethyl 3-(pyridin-2-ylamino)propanoate involves a carefully controlled chemical process. Typically, it is synthesized using 2-aminopyridine and ethyl acrylate as the primary raw materials. The reaction is often carried out in an anhydrous ethanol solvent and catalyzed by trifluoromethanesulfonic acid. Under specific temperature conditions, usually between 120-160°C, and under nitrogen protection for an extended period (16-20 hours), the catalytic reaction yields the desired product. Subsequent purification steps, including washing and recrystallization, ensure the high purity characteristic of this white powder intermediate.

The molecular structure of Ethyl 3-(pyridin-2-ylamino)propanoate, C10H14N2O2, with a molecular weight of 194.23 g/mol, is designed for specific chemical reactivity that makes it an ideal precursor for various pharmaceutical compounds. Its application as an intermediate in the synthesis of Dabigatran Etexilate, a crucial direct thrombin inhibitor, underscores its significance in the development of anticoagulant therapies. The increasing need for such medications makes the efficient and reliable synthesis of this intermediate a cornerstone of pharmaceutical manufacturing.

Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. invest in advanced synthesis techniques and stringent quality control measures to guarantee the consistency and purity of Ethyl 3-(pyridin-2-ylamino)propanoate. This attention to detail is critical, as any impurities could affect the efficacy and safety of the final drug product. By maintaining high standards in production, NINGBO INNO PHARMCHEM CO.,LTD. ensures that pharmaceutical companies can confidently buy this intermediate for both research and large-scale production.

The properties of Ethyl 3-(pyridin-2-ylamino)propanoate, including its solubility in DMSO and methanol and its stability when stored under specific conditions (dark place, inert atmosphere, 2-8°C), are key considerations for its handling and storage throughout the supply chain. NINGBO INNO PHARMCHEM CO.,LTD. adheres to best practices in warehousing and logistics to ensure the integrity of the product until it reaches the customer.

In essence, the chemical synthesis of Ethyl 3-(pyridin-2-ylamino)propanoate is a testament to the precision required in pharmaceutical intermediate manufacturing. NINGBO INNO PHARMCHEM CO.,LTD., as a leading supplier from China, is committed to advancing pharmaceutical development by providing this vital building block. For organizations looking to procure this essential chemical, understanding its synthesis and the quality assurance provided by manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. is key to a successful partnership.